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首页> 外文期刊>AIDS care. >Alcohol use predicts elevation in inflammatory marker soluble CD14 in men living with HIV
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Alcohol use predicts elevation in inflammatory marker soluble CD14 in men living with HIV

机译：饮酒可预测艾滋病毒感染者的炎症标志物可溶性CD14升高

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Independently, HIV infection and heavy alcohol use increase microbial translocation (MT) of gut products into systemic circulation. MT and consequent immune response have been linked to chronic inflammation and a host of negative health outcomes in individuals living with HIV. However, previous research has not systematically investigated the immune correlates of heavy drinking specifically within the HIV-positive population. This pilot study investigated MT and immune activation as a function of alcohol use in 21 HIV-positive men who met NIAAA criteria for heavy drinking. Participants averaged 46.7 +/- 8.5 (mean +/- standard deviation) years of age, 12.2 +/- 9.2 years since HIV diagnosis, 337 +/- 158 CD4 nadir, and 643 +/- 245 current CD4 count. All participants were virologically suppressed on antiretroviral therapy. Data on alcohol use and immune function were collected at baseline and three-month follow-up. Plasma concentrations of markers of MT and immune activation (lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody immunoglobulin M (EndoCAb)) were measured using enzyme-linked immunosorbent assays. Generalized estimating equation models tested alcohol use variables as predictors of LPS, sCD14, and EndoCAb levels. Greater quantity and frequency of drinking significantly predicted higher sCD14 levels (p's<.01). Conversely, longer duration of abstinence from alcohol significantly predicted lower sCD14 levels (p<.001). These results remained significant after controlling for age, HIV duration, smoking status, current CD4 count, CD4 nadir, and antiretroviral drug type. In addition, participants with 50% relative reduction in drinks per week showed a significant decrease (p<.05) in sCD14 from baseline to three-month follow-up. This pilot study provides preliminary evidence that heavy drinking may increase a key inflammatory marker in HIV-infected individuals with suppressed infection.
机译：独立地，HIV感染和大量饮酒会增加肠道产品进入系统循环的微生物移位（MT）。 MT和随之而来的免疫反应与感染艾滋病毒的人的慢性炎症和许多负面健康结果有关。但是，以前的研究尚未系统地研究大量饮酒的免疫相关性，特别是在HIV阳性人群中。这项前瞻性研究调查了21名符合NIAAA大量饮酒标准的HIV阳性男性中MT和免疫激活与饮酒的关系。参与者的平均年龄为46.7 +/- 8.5岁（平均+/-标准差），自HIV诊断以来为12.2 +/- 9.2岁，337 +/- 158 CD4最低点，以及643 +/- 245当前的CD4计数。所有参与者在抗逆转录病毒疗法上均受到病毒学抑制。在基线和三个月的随访中收集了有关酒精使用和免疫功能的数据。使用酶联免疫吸附测定法测量血浆中MT标记物和免疫激活（脂多糖（LPS），可溶性CD14（sCD14），内毒素核心抗体免疫球蛋白M（EndoCAb））的浓度。广义估计方程模型测试了酒精使用变量作为LPS，sCD14和EndoCAb水平的预测指标。大量饮酒和饮酒次数显着预测了更高的sCD14水平（p's <.01）。相反，戒酒的时间越长，则表明sCD14水平越低（p <.001）。在控制了年龄，HIV持续时间，吸烟状况，当前CD4计数，CD4最低点和抗逆转录病毒药物类型之后，这些结果仍然很显着。此外，每周饮酒量相对减少50％的参与者显示sCD14从基线到三个月的随访时间显着减少（p <.05）。这项初步研究提供了初步的证据，即大量饮酒可能会增加感染被抑制的HIV感染者的关键炎症标志物。

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