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Canine Copper-Associated Hepatitis

机译:犬铜相关的肝炎

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摘要

Copper-associated hepatitis is recognized with increasing frequency in dogs. The disease is characterized by centrolobular hepatic copper accumulation, leading to hepatitis and eventually cirrhosis. The only way to establish the diagnosis is by histologic assessment of copper distribution and copper quantification in a liver biopsy. Treatment with the copper chelator o-penicillamine is the most commonly used treatment. In addition, a low-copper/highzinc diet can help prevent accumulation or reaccumulation of hepatic copper. Mutations in the copper metabolism genes COMMD1 or ATP7A and ATP7B have been associated with hepatic copper concentrations in Bedlington terriers and Labrador retrievers respectively. In the Labrador retriever, dietary copper intake contributes strongly to the disease phenotype.
机译:铜相关的肝炎因犬频率的增加而被认可。 该疾病的特点是肝细胞覆盖积聚,导致肝炎和最终肝硬化。 建立诊断的唯一方法是通过肝脏活组织检查中的铜分布和铜定量的组织学评估。 用铜螯合剂O-青霉素治疗是最常用的治疗方法。 此外,低铜/浓度饮食可以有助于预防肝铜的积累或reacrumulululululululululululation。 铜代谢基因Commd1或ATP7A和ATP7B中的突变分别与伯灵顿纬线和拉布拉多术后的肝铜浓度有关。 在拉布拉多猎犬中,膳食铜摄入量强烈对疾病表型有助于。

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