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首页> 外文期刊>AIDS Research and Human Retroviruses >Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function
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Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function

机译：HIV感染，代谢危险因素与左心室结构与功能之间的关系

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Our objective was to determine if the presence of metabolic complications (MC) conveyed an additional risk for left ventricular (LV) dysfunction in people with HIV. HIV+ and HIV- men and women were categorized into four groups: (1) HIV+ with MC (43±7 years, n=64), (2) HIV+ without MC (42±7 years, n=59), (3) HIV- with MC (44±8 years, n=37), or (4) HIV- controls without MC (42±8 years, n=41). All participants underwent two-dimensional (2-D), Doppler, and tissue Doppler echocardiography. Overall, the prevalence of systolic dysfunction (15 vs. 4%, p=0.02) and LV hypertrophy (9 vs. 1%, p=0.03) was greater in HIV+ than in HIV- participants. Participants with MC had a greater prevalence of LV hypertrophy (10% vs. 1%). Early mitral annular velocity during diastole was significantly (p0.005) lower in groups with MC (HIV+/MC+: 11.6±2.3, HIV-/MC+: 12.0±2.3 vs. HIV+/MC -: 12.4±2.3, HIV-/MC-: 13.1±2.4 cm/s) and tended to be lower in groups with HIV (p=0.10). However, there was no interaction effect of HIV and MC for any systolic or diastolic variable. Regardless of HIV status, participants with MC had reduced LV diastolic function. Although both the presence of MC and HIV infection were associated with lower diastolic function, there was no additive negative effect of HIV on diastolic function beyond the effect of MC. Also, HIV was independently associated with lower systolic function. Clinical monitoring of LV function in individuals with metabolic risk factors, regardless of HIV status, is warranted.
机译：我们的目标是确定在HIV感染者中是否存在代谢并发症（MC）带来了左心室（LV）功能障碍的其他风险。 HIV +和HIV-男女分为四组：（1）带有MC的HIV +（43±7岁，n = 64），（2）没有MC的HIV +（42±7岁，n = 59），（3）患有MC的HIV患者（44±8岁，n = 37），或（4）没有MC的HIV对照患者（42±8岁，n = 41）。所有参与者均进行了二维（2-D），多普勒和组织多普勒超声心动图检查。总体而言，HIV +患者的收缩功能障碍（15 vs. 4％，p = 0.02）和LV肥大（9 vs. 1％，p = 0.03）的患病率高于HIV参与者。患有MC的参与者左室肥大的患病率更高（10％vs. 1％）。患有MC的人群舒张期早期二尖瓣环速度明显降低（p <0.005）（HIV + / MC +：11.6±2.3，HIV- / MC +：12.0±2.3 vs.HIV + / MC-：12.4±2.3，HIV- / MC -：13.1±2.4 cm / s），并且在HIV感染人群中较低（p = 0.10）。但是，对于任何收缩或舒张变量，HIV和MC均无相互作用。不论HIV状况如何，MC参与者的LV舒张功能均降低。尽管MC和HIV感染均与舒张功能降低有关，但除了MC以外，HIV对舒张功能没有附加的负面影响。而且，HIV与收缩功能降低独立相关。无论是否患有艾滋病毒，均应临床监测具有代谢危险因素的个体的左室功能。

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