• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS Research and Human Retroviruses >Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals.
【24h】

Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals.

机译：美国国家过敏和传染病研究所研讨会的成果，以了解暴露于艾滋病毒但血清反应阴性的个体。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The fascinating conundrum that some individuals who are exposed to HIV in ways that would make viral transmission highly likely, yet are able to remain uninfected, has been appreciated for many years. As early as the late 1980s, reports of such individuals began appearing in the HIV/AIDS literature. Despite the critical importance of understanding possible mechanisms of natural HIV resistance for developing effective prevention strategies, numerous obstacles have prevented this essential area of scientific exploration from moving forward. The Workshop held on July 8-9, 2010 and supported by the Office of AIDS Research (OAR), the National Institute of Allergy and Infectious Diseases (NIAID), and the National Institute on Drug Abuse (NIDA) at the NIH hosted 200 participants and utilized the expertise of 42 AIDS researchers as invited speakers, session chairs, and discussion leaders for presentations and breakout sessions in an attempt to remove some of those obstacles. Accomplishments of the participants included developing a consensus for a new general term for the field, HIV-exposed seronegative (HESN), while recognizing the necessity to identify and utilize secondary descriptive criteria such as exposure level, risk group, duration of seronegativity, or natural resistance. Three key questions for future research were also identified by the group: (1) What is different in HESN versus those who get infected? (2) What is the immune response in HESN and is it just a marker of exposure or a correlate of protection? (3) What are the HESN host factors that help HESN resist infection? This report briefly summarizes the presentations, and describes future directions for addressing these questions and challenges.
机译：令人困惑的难题是，许多人暴露于艾滋病毒中的方式很可能会导致病毒传播，但仍然能够保持未被感染的状态，这已经引起了很多年的赞赏。早在1980年代末，有关此类个体的报道就开始出现在HIV / AIDS文献中。尽管了解可能的天然HIV抗药性机制对于制定有效的预防策略至关重要，但许多障碍阻碍了这一重要的科学探索领域的前进。该研讨会于2010年7月8日至9日举行，在美国国立卫生研究院的艾滋病研究办公室（OAR），美国国家过敏和传染病研究所（NIAID）和美国国家药物滥用研究所（NIDA）的支持下，共有200人参加并邀请了42名艾滋病研究人员的专业知识作为演讲嘉宾，会议主席和讨论负责人进行演讲和分组讨论，以期消除其中的一些障碍。参与者的成就包括就该领域的新通用术语即HIV暴露的血清阴性（HESN）达成共识，同时认识到有必要识别和利用次要的描述性标准，例如暴露水平，风险组，血清阴性持续时间或自然抵抗性。该小组还确定了未来研究的三个关键问题：（1）HESN与被感染者有何不同？ （2）HESN中的免疫反应是什么，它仅仅是暴露的标志还是保护的关联？ （3）帮助HESN抵抗感染的HESN宿主因素有哪些？本报告简要总结了演讲内容，并描述了解决这些问题和挑战的未来方向。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号