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Molecular epidemiological analysis of paired pol/env sequences from Portuguese HIV type 1 patients.

机译:葡萄牙1型HIV患者配对pol / env序列的分子流行病学分析。

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摘要

The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14_BGpol/Genv (7.2%).
机译:针对环境的新治疗方法的出现以及对有效抗HIV-1疫苗的寻找,使得有必要使用以前不经常测序的基因组区域来鉴定重组形式的数量。在这项研究中,我们对来自HIV-1菌株的pol和env序列进行亚型分型,感染了葡萄牙的152名患者。在pol和env中发现不一致亚型的菌株百分比为25.7%。当pol和env中的亚型一致时(65.1%),最普遍的亚型是B亚型(40.8%),其次是C亚型(17.8%)和G亚型(5.3%)。最普遍的重组形式是CRF14_BGpol / Genv(7.2%)。

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