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首页> 外文期刊>AIDS Research and Human Retroviruses >Prevalence of genotypic resistance to antiretroviral drugs in treatment-naive youths infected with diverse HIV type 1 subtypes and recombinant forms in Dar es Salaam, Tanzania.
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Prevalence of genotypic resistance to antiretroviral drugs in treatment-naive youths infected with diverse HIV type 1 subtypes and recombinant forms in Dar es Salaam, Tanzania.

机译：在坦桑尼亚达累斯萨拉姆，感染多种HIV 1型亚型和重组形式的未接受治疗的未成年人中，对抗逆转录病毒药物的基因型耐药性普遍存在。

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As human immunodeficiency virus (HIV) diversity may have an impact on both vaccine efficacy and drug resistance, it is important to have knowledge of circulating genetic variants. With widespread use of antiretroviral (ARV) drugs in Africa, one of the major potential challenges is the risk of emergence of ARV drug-resistant HIV strains. This study aimed to determine the circulating HIV subtypes and recombinant forms, as well as the prevalence of ARV drug resistance mutations, among 75 treatment-naive HIV-infected youths in Dar es Salaam, Tanzania. Gag (n = 48), partial pol (n = 44), and partial env (n = 35) sequencing was performed; all three regions were sequenced in 26 samples. Evidence of infection with recombinant viruses was found in 12 (46%) participants; AC recombinants were the most commonly detected and they were identified in six (23%) participants. Of individuals infected with nonrecombinant strains, subtype A was most commonly detected in seven (27%) participants, followed by subtype C detected in six (23%) participants and subtype D detected in one (4%) participant. Among the pol sequences from 44 individuals, three (7%) had resistance to nucleoside reverse transcriptase (RT) inhibitors and four (9%) had nonnucleoside RT inhibitor resistance mutations. Of these, three (7%) individuals were infected with viruses with cross-resistance mutations to both classes of RT inhibitors. These resistant mutations were all associated with drugs currently used in first-line therapy and in the prevention of vertical transmission. This high prevalence of resistance mutations is of considerable concern in apparently drug-naive populations as it may result in treatment failure and the spread of ARV-resistant strains.
机译：由于人类免疫缺陷病毒（HIV）的多样性可能会影响疫苗效力和耐药性，因此了解循环遗传变异非常重要。随着非洲抗逆转录病毒（ARV）药物的广泛使用，主要的潜在挑战之一是抗ARV耐药HIV菌株出现的风险。这项研究旨在确定坦桑尼亚达累斯萨拉姆（Dar es Salaam）的75名未接受过治疗的HIV感染青年中正在传播的HIV亚型和重组形式，以及ARV耐药性突变的患病率。进行Gag（n = 48），部分pol（n = 44）和部分env（n = 35）测序;这三个区域均在26个样品中测序。在12名（46％）的参与者中发现了重组病毒感染的证据。 AC重组体是最常检测到的，在六名（23％）参与者中被鉴定出。在感染非重组毒株的个体中，最常见的是在7名（27％）参与者中检测到A型，其次是在6名（23％）参与者中检测到C型，在一名（4％）参与者中发现了D型。在来自44个个体的pol序列中，三个（7％）具有对核苷逆转录酶（RT）抑制剂的抗性，四个（9％）具有非核苷RT抑制剂的抗性突变。其中，三（7％）个人感染了对两种RT抑制剂均具有交叉耐药突变的病毒。这些抗药性突变都与目前用于一线治疗和预防垂直传播的药物有关。耐药突变的这种高流行在显然没有药物的人群中引起了极大的关注，因为它可能导致治疗失败和抗ARV菌株的传播。

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