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首页> 外文期刊>AIDS Research and Human Retroviruses >HIV type 1 origin and transmission dynamics among different risk groups in Sardinia: Molecular epidemiology within the close boundaries of an Italian Island
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HIV type 1 origin and transmission dynamics among different risk groups in Sardinia: Molecular epidemiology within the close boundaries of an Italian Island

机译：撒丁岛不同风险人群之间的1型HIV起源和传播动态：在意大利小岛附近的分子流行病学

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In Italy, the HIV-1 epidemic is still mainly sustained by the subtype B genetic form, although other and novel subtypes and circulating recombinant forms (CRFs) have been reported. A total of 215 HIV-1 pol gene sequences were collected between 1992 and 2010. Multiple alignments spanning subtype-specific HIV-1 B pol sequences were analyzed by Bayesian phylogenetic methods. Subtype B represented 90.7% (n=195) of the sequences. Three main clusters were detected. The root of the tree dated to 1987. Most of the observed viral gene flow events occurred from heterosexual to intravenous drug users (IDUs). Phylogenetic and molecular clock analysis showed an early HIV-1 subtype B introduction in the mid-1980s and dissemination within local risk-specific clusters. This is the first study to describe in detail the HIV-1 molecular epidemiology in one of the largest islands in the European basin. The future potential of the Sardinian epidemic as a hub between Southern and Northern Europe has to been considered.
机译：在意大利，尽管有其他新颖的亚型和循环重组形式（CRF）报道，但HIV-1流行仍主要由B型亚型维持。在1992年至2010年之间，总共收集了215个HIV-1 pol基因序列。采用贝叶斯系统发育分析方法分析了跨亚型特异性HIV-1 B pol序列的多重比对。 B亚型代表序列的90.7％（n ＝ 195）。检测到三个主要簇。该树的根可追溯至1987年。观察到的大多数病毒基因流动事件均发生于异性恋者至静脉吸毒者（IDU）。系统发育和分子时钟分析表明，1980年代中期早期引入了HIV-1 B型亚型，并在局部特定风险人群中传播。这是第一个详细描述欧洲盆地最大岛屿之一中HIV-1分子流行病学的研究。必须考虑撒丁岛流行病作为南欧和北欧之间枢纽的未来潜力。

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