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Transmitted HIV Type 1 Drug Resistance in Newly Diagnosed Cuban Patients

机译：在新诊断的古巴患者中传播的1型HIV耐药性

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摘要

Knowledge of the associated mutations to transmitted drug resistance (TDR) in strains of human immunodeficiency virus type 1 (HIV-1) constitutes a fundamental premise in epidemiological surveillance. In this present study, TDR from 200 Cuban patients who were diagnosed with HIV-1 between 2009 and 2011 was analyzed. By partial reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing of the HTV pol gene, an HIV subtype and transmitted resistance profile were determined. The prevalence of associated mutations to the TDR in the individuals studied was 21.5%. In the region of the reverse transcriptase, the most common mutations were K103N and Ml84V, while in the region of the protease they were L33F and M46L. The results of this study provide evidence of TDR in the Cuban seropositive population and suggest the necessity of making resistance assays before beginning antiretroviral therapy in HIV-1-infected patients in Cuba.
机译：了解人类免疫缺陷病毒1型（HIV-1）株中传播耐药性（TDR）的相关突变是流行病学监测的基本前提。在本研究中，分析了2009年至2011年之间200例被诊断为HIV-1的古巴患者的TDR。通过部分逆转录酶聚合酶链反应（RT-PCR）和HTV pol基因测序，确定了HIV亚型和传播的耐药性。在所研究的个体中，与TDR相关的突变的患病率为21.5％。在逆转录酶区域，最常见的突变是K103N和M18V，而在蛋白酶区域，它们是L33F和M46L。这项研究的结果提供了古巴血清反应阳性人群中TDR的证据，并表明在古巴接受HIV-1感染的患者开始抗逆转录病毒治疗之前必须进行耐药性分析。

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