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首页> 外文期刊>AIDS Research and Human Retroviruses >The effect of cholecalciferol and calcitriol on biochemical bone markers in HIV type 1-infected males: Results of a clinical trial
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The effect of cholecalciferol and calcitriol on biochemical bone markers in HIV type 1-infected males: Results of a clinical trial

机译：胆钙化固醇和骨化三醇对感染1型HIV的男性生化指标的影响：一项临床试验的结果

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HIV-1-infected patients have an increased risk of osteoporosis and fractures. The main objective of this study was to evaluate the bone metabolism in HIV-1-infected patients exposed to calcitriol and cholecalciferol. We also investigated the relationship between T cells and bone markers. We conducted a placebo-controlled randomized study running for 16 weeks including 61 HIV-1-infected males, of whom 51 completed the protocol. Nineteen participants were randomized to daily treatment with (A) 0.5-1.0 μg calcitriol and 1,200 IU (30 μg) cholecalciferol, 17 participants to (B) 1,200 IU cholecalciferol, and 15 participants to (C) placebo. At baseline and after 16 weeks, we determined collagen type 1 trimeric cross-linked peptide (CTx), procollagen type 1 N-terminal peptide (P1NP), parathyroid hormone (PTH), ionized calcium, 25-hydroxyvitamin D (25OHD), and 1,25-dihydroxyvitamin D [1,25(OH) 2D]. We determined naive CD4+ and CD8+, activated CD4+ and CD8+, and regulatory CD4 +CD25+CD127(low) T lymphocytes. Baseline levels of P1NP and CTx correlated (coefficient 0.5, p0.001) with each other but not with PTH, 25OHD, or 1,25(OH)2D. In patients receiving calcitriol and cholecalciferol, the mean levels of P1NP (p0.001) and CTx (p= 0.002) declined significantly compared to our placebo group. Based on changes in P1NP and CTx, we estimated that net bone formation occurred more frequently in group A compared to groups B and C. PTH correlated inversely with naive CD4 + and CD8+ cells. Otherwise, no relationships between bone markers and T lymphocytes were demonstrated. Supplementation with calcitriol and cholecalciferol induced biochemical indications of bone formation in HIV-1 patients.
机译：感染HIV-1的患者患骨质疏松症和骨折的风险增加。这项研究的主要目的是评估暴露于骨化三醇和胆钙化固醇的HIV-1感染患者的骨代谢。我们还研究了T细胞和骨标志物之间的关系。我们进行了一项为期16周的安慰剂对照随机研究，其中包括61位感染HIV-1的男性，其中51位完成了方案。 19名参与者被随机分配到接受（A）0.5-1.0μg骨化三醇和1,200 IU（30μg）胆钙化固醇，17名参与者（B）1,200 IU胆钙化固醇和15名参与者（C）安慰剂的每日治疗中。在基线和16周后，我们确定了1型胶原三聚体交联肽（CTx），1型胶原蛋白N端肽（P1NP），甲状旁腺激素（PTH），钙离子，25-羟基维生素D（25OHD）和1,25-二羟基维生素D [1,25（OH）2D]。我们确定了幼稚的CD4 +和CD8 +，活化的CD4 +和CD8 +以及调节性CD4 + CD25 + CD127（低）T淋巴细胞。 P1NP和CTx的基线水平相互关联（系数0.5，p <0.001），但与PTH，25OHD或1,25（OH）2D不相关。与我们的安慰剂组相比，接受骨化三醇和胆钙化醇的患者的P1NP（p <0.001）和CTx（p = 0.002）的平均水平显着下降。根据P1NP和CTx的变化，我们估计与B和C组相比，A组的净骨形成更为频繁。PTH与天然CD4 +和CD8 +细胞成反比。否则，没有显示出骨标志物与T淋巴细胞之间的关系。补充骨化三醇和胆钙化固醇可诱导HIV-1患者骨形成的生化指标。

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