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首页> 外文期刊>AIDS Research and Human Retroviruses >Molecular epidemiology of HIV type 1 subtypes in Rwanda
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Molecular epidemiology of HIV type 1 subtypes in Rwanda

机译：卢旺达HIV 1型亚型的分子流行病学

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HIV-1 infection is characterized by genetic diversity, with multiple subtypes and recombinant variants circulating, particularly in sub-Saharan Africa. During the Rwandan genocide, many women experienced multiple rapes and some became HIV-1 infected. We studied plasma and peripheral blood mononuclear cells (PBMCs) from 30 infected women comprising two exposure groups: those with numerous contacts, raped multiple times, and women with one lifetime sexual partner and no history of rape. Population-based sequences from gag, pol, and env genes were analyzed to determine HIV-1 subtypes and intersubtype recombination. Individual plasma-derived variants from 12 women were also analyzed. Subtype A was found in 24/30 (80%), intersubtype recombination (AC and AD) in 4/30 (13%), and subtypes C and D in 1/30 each. In two subjects, the pattern of HIV-1 recombination differed between plasma and PBMC-derived sequences. Intersubtype recombination was common, although there were no significant differences in subtype or recombination rates between exposure groups.
机译：HIV-1感染的特征是遗传多样性，尤其是在撒哈拉以南非洲，存在着多种亚型和重组变异体。在卢旺达种族灭绝大屠杀期间，许多妇女遭受了多次强奸，有一些妇女感染了HIV-1。我们研究了30名受感染妇女的血浆和外周血单核细胞（PBMC），包括两个暴露组：接触次数多，被强奸多次的妇女以及有一个终身性伴侣且没有强奸病史的妇女。分析了来自gag，pol和env基因的基于人群的序列，以确定HIV-1亚型和亚型间的重组。还分析了来自12位女性的血浆衍生变异体。发现亚型A的比例为24/30（80％），发现亚型重组（AC和AD）的比例为4/30（13％），而C和D的亚型分别为1/30。在两个受试者中，血浆和PBMC衍生序列之间的HIV-1重组模式不同。亚型间重组很常见，尽管暴露组之间亚型或重组率没有显着差异。

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