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首页> 外文期刊>AIDS Research and Human Retroviruses >Current molecular epidemiology and recombination of HIV type 1 subtypes in northern Thailand.
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Current molecular epidemiology and recombination of HIV type 1 subtypes in northern Thailand.

机译：泰国北部目前的分子流行病学和HIV 1型亚型的重组。

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摘要

HIV subtype characterization is an important tool to monitor the genetic variation of the HIV epidemic. This study investigated the current HIV subtype distribution and recombination among the northern Thai population. An in-house genotypic assay of HIV protease and reverse transcriptase genes was performed on 420 plasma specimens from HIV-infected patients residing in several northern Thai provinces. HIV subtyping was determined by phylogenetic analysis. Three hundred and ninety-eight sequences (94.8%) were identified as CRF01_AE with the genetic distance of 1.848 +/- 0.957% and 12 (2.9%) as subtype B with the genetic distance of 4.186 +/- 0.849%. In addition, two sequences (0.5%) of HIV subtype C were found, suggesting that these patients were either immigrants from another country or were infected through heterosexual contact with HIV-infected subjects from another country. Bootscan analysis showed that there were eight (1.9%) unique recombinant forms (URFs) consisting of a recombinant of CRF01_AE with subtype B or subtype C. The information from this study is useful for prevention programs to halt the onward transmission of a particular HIV outbreak. However, characterization of the full genome of these CRF01_AE/B and CRF01_AE/C intersubtype recombinants, and also subtype C, is required for confirmation and elucidation.
机译：HIV亚型表征是监测HIV流行的遗传变异的重要工具。这项研究调查了泰国北部人口中当前的HIV亚型分布和重组。对泰国北部几个省的HIV感染患者的420份血浆标本进行了HIV蛋白酶和逆转录酶基因的内部基因型分析。通过系统发育分析确定HIV亚型。 138个序列（94.8％）被鉴定为CRF01_AE，遗传距离为1.848 +/- 0.957％，12个序列（2.9％）被鉴定为B亚型，遗传距离为4.186 +/- 0.849％。此外，发现了两个序列（0.5％）的HIV C亚型，表明这些患者要么是来自另一个国家的移民，要么是通过与另一个国家的HIV感染者的异性接触而感染的。 Bootscan分析表明，共有八种（1.9％）独特重组形式（URF），由具有B型或C型亚型的CRF01_AE重组体组成。该研究的信息可用于预防计划，以阻止特定HIV爆发的继续传播。但是，对这些CRF01_AE / B和CRF01_AE / C间亚型重组体以及C亚型的完整基因组进行表征，对于确认和阐明是必需的。

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