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首页> 外文期刊>AIDS Research and Human Retroviruses >Frequent intratype neutralization by plasma immunoglobulin a identified in HIV type 2 infection
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Frequent intratype neutralization by plasma immunoglobulin a identified in HIV type 2 infection

机译：在HIV 2型感染中通过血浆免疫球蛋白a频繁进行中型内中和

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Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4+ T cell count, the plasma viral load in HIV-2-infected individuals is approximately one log lower than in HIV-1-infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2, and HIV-1/HIV-2 dually (HIV-D) infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific neutralization by IgA was frequently detected, although at a lesser magnitude then the corresponding IgG neutralizing titers. In contrast, neutralization by IgA could rarely be demonstrated in HIV-1 infection despite similar plasma IgA levels in both infections. In addition, IgA and IgG of HIV-D plasma neutralized the HIV-2 isolate more potently than the HIV-1 isolate, suggesting that the difference between neutralizing activity of plasma IgA and IgG depends on the virus itself. Taken together, these findings suggest that both IgA and IgG add to the potent intratype neutralizing activity detected in HIV-2 plasma, which may contribute to virus control in HIV-2 infection.
机译：与HIV-1相比，人类2型免疫缺陷病毒（HIV-2）的传播性和致病性更低，与CD4 + T细胞计数相匹配时，HIV-2感染者的血浆病毒载量比HIV-1低大约一个对数-1-感染个体。这些观察结果的解释难以捉摸，但是两种感染中产生的病毒控制免疫力的差异可能是造成这种情况的因素。在本研究中，我们调查了免疫球蛋白A（IgA）与IgG的平行中和作用，并从受HIV-1，HIV-2和HIV-1 / HIV-2双重感染（HIV-D）的血浆中纯化得到。使用噬斑减少测定法针对HIV-1和HIV-2分离株进行中和分析。在HIV-2感染中，虽然与相应的IgG中和效价相比幅度较小，但经常会检测到IgA进行的型内特异性中和。相比之下，尽管在两种感染中血浆IgA水平相似，但很少在HIV-1感染中表现出IgA中和作用。此外，HIV-D血浆的IgA和IgG比HIV-1分离株更有效地中和HIV-2分离株，表明血浆IgA和IgG的中和活性之间的差异取决于病毒本身。综上所述，这些发现表明，IgA和IgG都增加了在HIV-2血浆中检测到的有效的型内中和活性，这可能有助于控制HIV-2感染中的病毒。

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