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首页> 外文期刊>AIDS Research and Human Retroviruses >Analysis of human immunodeficiency virus type 1 Vif gene sequences among men who have sex with men in heilongjiang province of China
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Analysis of human immunodeficiency virus type 1 Vif gene sequences among men who have sex with men in heilongjiang province of China

机译：中国黑龙江省男男性接触者免疫缺陷病毒1型Vif基因序列分析

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摘要

To identify the current prevalent subtypes and to study the genetic variation of HIV-1 strains in men who have sex with men (MSM) residing in Heilongjiang province, China. We analyzed the characteristics of the nucleotide sequences and the corresponding deduced protein of Vif of HIV-1 strains isolated from 17 drug-naive HIV-1-seropositive MSM. Subtypes B (7.65%) and B′ (Thailand B) (11.76%), CRF07-BC (47.06%), and CRF01-AE (23.53%) were identified. Phylogenetic analysis showed that there was a close relationship between our strains and those from the same MSM population in Hebei province, which is geographically close to Heilongjiang. Most of the documented Vif functional motifs are well conserved in the majority of our analyzed sequences. Taken together, our results suggest that there might be multiple introductions of HIV in Heilongjiang MSM and frequent sexual communications with other geographically nearby MSM populations.
机译：为了确定当前流行的亚型，并研究中国黑龙江省男男性接触者中HIV-1病毒的遗传变异。我们分析了从17种未经药物治疗的HIV-1血清阳性MSM分离的HIV-1菌株的核苷酸序列和相应推导的Vif蛋白的特征。鉴定出亚型B（7.65％）和B'（泰国B）（11.76％），CRF07-BC（47.06％）和CRF01-AE（23.53％）。系统发育分析表明，我们的菌株与河北省MSM相同种群的菌株之间有着密切的关系，而河北省在地理上靠近黑龙江。在我们分析的大多数序列中，大多数已记录的Vif功能性基序都非常保守。综上所述，我们的结果表明，黑龙江MSM中可能多次引入HIV，并且与附近其他地理位置的MSM人群频繁发生性传播。

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