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首页> 外文期刊>AIDS Research and Human Retroviruses >Male genital tract compartmentalization of human immunodeficiency virus type 1 (HIV).
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Male genital tract compartmentalization of human immunodeficiency virus type 1 (HIV).

机译：人类1型人类免疫缺陷病毒（HIV）的男性生殖道分隔。

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摘要

We present phylogenetic evidence supporting viral compartmentalization between the blood (peripheral blood mononuclear cells or plasma) and multiple genitourinary sites in HIV-infected men. Four of the five subjects evaluated demonstrated compartmentalization of viral sequences between urogenital tract specimens (tissue or fluid) and at least one blood category. HIV sequence migration from blood to urogenital tract was detected in four of five men, with migration from urogenital tract to blood in the fifth, and cross migration between both compartments noted in one man. These observations add 5 additional cases to the 27 total reported cases in which male urogenital tract compartmentalization has been studied, investigate surgical samples/specimens that have not been evaluated previously, and provide further evidence for restricted flow of HIV between the blood and the genital tract. As such, our study findings are important for understanding the long-term response to antiretroviral therapy, the designof vaccines, and the sexual transmission of HIV.
机译：我们提出了系统发育证据，支持在艾滋病毒感染男性的血液（外周血单个核细胞或血浆）与多个泌尿生殖系统部位之间进行病毒区室化。被评估的五名受试者中有四名表现出泌尿生殖道标本（组织或体液）与至少一种血液类别之间的病毒序列分隔。五名男子中有四名检测到HIV序列从血液向泌尿生殖道迁移，第五名中有从泌尿生殖道向血液迁移，一名男子在两个隔室之间发生交叉迁移。这些观察结果增加了27例报告的男性泌尿生殖道分隔的报告病例中的5例，调查了以前未进行过评估的手术样本/标本，并为HIV在血液与生殖道之间流动受限提供了进一步的证据。因此，我们的研究结果对于理解抗逆转录病毒疗法的长期反应，疫苗的设计以及HIV的性传播非常重要。

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