Impact of Cachexia and Opioid Analgesic Cotreatment on Pregabalin Pharmacokinetics and Central Nervous System Symptoms in Cancer Patients

Yoshikawa Nozomi; Naito Takafumi; Yagi Tatsuya; Kawakami Junichi

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Impact of Cachexia and Opioid Analgesic Cotreatment on Pregabalin Pharmacokinetics and Central Nervous System Symptoms in Cancer Patients

机译：CACHEXIA和阿片类药物镇痛COTEATEATEM对癌症患者普瑞巴林药代动力学和中枢神经系统症状的影响

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Background: Patients with cancer receiving pregabalin potentially have a high incidence of central nervous system (CNS) symptoms. The purpose of this study was to explore clinical factors influencing the incidence of CNS symptoms, including plasma pregabalin exposure, cancer cachexia, and opioid analgesic cotreatment.

机译：背景：癌症接受普雷巴林的患者可能具有中枢神经系统（CNS）症状的高发病率。本研究的目的是探讨影响CNS症状的发病率的临床因素，包括血浆普瑞巴林暴露，癌症恶病症和阿片类镇痛的分类。

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来源
《Therapeutic Drug Monitoring》 |2019年第5期|共7页
作者
Yoshikawa Nozomi; Naito Takafumi; Yagi Tatsuya; Kawakami Junichi;
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作者单位

Hamamatsu Univ Sch Med Dept Hosp Pharm Hamamatsu Shizuoka Japan;

Hamamatsu Univ Sch Med Dept Hosp Pharm Hamamatsu Shizuoka Japan;

Hamamatsu Univ Sch Med Dept Hosp Pharm Hamamatsu Shizuoka Japan;

Hamamatsu Univ Sch Med Dept Hosp Pharm Hamamatsu Shizuoka Japan;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
pregabalin; CNS symptoms; plasma concentrations; cancer cachexia; opioid analgesics;

机译：Praetabalin;CNS症状;血浆浓度;癌症恶病症;阿片类镇痛药;

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1. Impact of Cachexia and Opioid Analgesic Cotreatment on Pregabalin Pharmacokinetics and Central Nervous System Symptoms in Cancer Patients [J] . Yoshikawa Nozomi, Naito Takafumi, Yagi Tatsuya, Therapeutic Drug Monitoring . 2019,第5期

机译：CACHEXIA和阿片类药物镇痛COTEATEATEM对癌症患者普瑞巴林药代动力学和中枢神经系统症状的影响
2. Impact of neratinib on development and progression of central nervous system (CNS) metastases in patients with HER2-positive metastatic breast cancer (MBC): Findings from the NALA, NEfERT-T, and TBCRC 022 trials [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：非替尼对Her2阳性转移乳腺癌患者中枢神经系统（CNS）转移的影响和进展的影响：NALA，Nefert-T和TBCRC 022试验的结果
3. Central Nervous System Disease, Education, and Race Impact Radiation Refusal in Pediatric Cancer Patients [J] . Patel Chirayu G., Stavas Mark, Perkins Stephanie, Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology . 2017,第5期

机译：中枢神经系统疾病，教育和种族影响儿科癌症患者的抗辐射拒绝
4. The impact of pregnancy on the pharmacokinetics of non-opioid analgesics [C] . Aida KULO, Rene VERBESSELT, Jan DE HOON, WSEAS international conference on medical physiology;WSEAS international conference on medical histology and embryology;WSEAS international conference on biochemistry and medical chemistry;WSEAS international conference on oncology;WSEAS international conference on medical pharmacology;WSEAS international conference on pathology;WSEAS international conference on psychiatry and psychotherapy;WSEAS international conference on cardiology;WSEAS international conference on surgery;WSEAS international conference on neurology;WSEAS international conference on gastroenterology;WSEAS international conference on ophthalmology;WSEAS international conference on obstetrics and gynaecology;WSEAS international conference on endocrinology . 2012

机译：怀孕对非阿片类镇痛药药代动力学的影响
5. Quantitative Investigation of Pharmacokinetics of Antibody-Based Therapeutics in the Central Nervous System [D] . Chang, Hsueh-Yuan. 2021

机译：中枢神经系统抗体治疗药物药代动力学的定量研究
6. ACTR-33. A PHASE I DOSE ESCALATION AND CENTRAL NERVOUS SYSTEM (CNS) PHARMACOKINETIC STUDY OF PULSATILE AFATINIB IN PATIENTS WITH BRAIN CANCER [O] . Tiffany Juarez, Najee Boucher, Annie Heng, 2017

机译：ACTR-33。 Ⅰ期DOSE标定和中枢神经系统（CNS）药动学研究在脑癌患者中的应用
7. INNV-41. MY STORI -- A SYMPTOM TRACKING AND REPORTING INSTRUMENT MOBILE APPLICATION FOR CENTRAL NERVOUS SYSTEM CANCER PATIENTS [O] . Xinyi Li, Elizabeth Vera, Mark Gilbert, 2018

机译：Innv-41。我的商店 - 一种症状跟踪和报告仪器移动应用于中枢神经系统癌症患者

Impact of Cachexia and Opioid Analgesic Cotreatment on Pregabalin Pharmacokinetics and Central Nervous System Symptoms in Cancer Patients

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