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Patterns of adherence to antiretrovirals: why adherence has no simple measure.

机译：坚持抗逆转录病毒药物的模式：为什么坚持没有简单的方法。

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摘要

The goal of this study was to explore patterns and explanations of adherence to antiretroviral therapies from the patient's perspective. It consisted of 78 in-depth interviews with patients attending an HIV clinic in New Orleans, Louisiana, to whom combination therapy had been prescribed. Interviews explored patient's definitions of adherence, beliefs about consequences of nonadherence, reasons for current and past adherence behavior, and contextual issues such as drug and alcohol use and social support. Respondents reported nine distinct patterns of adherence, which they perceived to have different consequences and causes. These patterns hid variations because respondents could have more than one pattern simultaneously and patterns were not stable over time. Although there are gold standards for adherence measurement, such as directly observed therapy, these measurements are most frequently used to classify respondents as adherers or nonadherers based on whether they take a certain percentage of theirmedication. Such a categorization is simplistic and does not reflect the complexity of adherence patterns.
机译：这项研究的目的是从患者的角度探讨坚持抗逆转录病毒疗法的模式和解释。它包括对在路易斯安那州新奥尔良市的一家艾滋病诊所就诊的患者的78次深度访谈，这些患者已接受了联合治疗的处方。访谈探讨了患者对依从性的定义，对不依从性后果的信念，当前和过去依从性行为的原因以及诸如吸毒和酗酒以及社会支持等背景问题。受访者报告了九种不同的依从模式，他们认为这会产生不同的后果和原因。这些模式隐藏了变化，因为受访者可能同时具有多个模式，并且随着时间的推移，模​​式也不稳定。尽管存在用于依从性测量的金标准，例如直接观察到的治疗，但是这些测量最常用于根据被访者是否服药的一定百分比将其归为依从性或非依从性。这种分类很简单，不能反映遵守模式的复杂性。

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