Short communication: severe immune suppression in patients infected with R5-tropic HIV-1 strains is associated with increased gp120 net charge at variable regions.

Seclen E; Soriano V; del Mar Gonzalez M; Gonzalez Lahoz J; Poveda E

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Short communication: severe immune suppression in patients infected with R5-tropic HIV-1 strains is associated with increased gp120 net charge at variable regions.

机译：简短交流：感染R5嗜性HIV-1菌株的患者严重的免疫抑制与可变区gp120净电荷增加有关。

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CXCR4-tropic viruses have been associated with advanced immune suppression. However, 50% of patients with AIDS exclusively harbor CCR5-tropic viruses. The net charge at HIV-1 envelope gp120 variable regions was examined in 66 HIV-1-infected individuals with CCR5-tropic viruses, of whom 30 had less than 200 cells/mm(3). A positive net charge at gp120 variable regions was significantly associated with lower CD4 counts. Thus, the net charge at gp120 variable regions could influence HIV-1 disease progression in subjects with CCR5-tropic viruses.

机译：CXCR4-tropic病毒与高级免疫抑制有关。但是，有50％的艾滋病患者仅携带CCR5嗜性病毒。在66位HIV-1感染的CCR5嗜性病毒个体中检查了HIV-1包膜gp120可变区的净电荷，其中30个体的细胞数少于200个/ mm（3）。 gp120可变区的正净电荷与较低的CD4计数显着相关。因此，gp120可变区的净电荷可能会影响患有CCR5嗜性病毒的受试者的HIV-1疾病进展。

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《AIDS Research and Human Retroviruses》 |2011年第9期|共3页
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Seclen E; Soriano V; del Mar Gonzalez M; Gonzalez Lahoz J; Poveda E;
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1. Short communication: severe immune suppression in patients infected with R5-tropic HIV-1 strains is associated with increased gp120 net charge at variable regions. [J] . Seclen E, Soriano V, del Mar Gonzalez M, AIDS Research and Human Retroviruses . 2011,第9期

机译：简短交流：感染R5嗜性HIV-1菌株的患者严重的免疫抑制与可变区gp120净电荷增加有关。
2. Association of maternal HIV-1 severity with dental caries: an observational study of uninfected 5-to 7-yr-old children of HIV-1-infected mothers without severe immune suppression [J] . Birungi Nancy, Fadnes Lars Thore, Engebretsen Ingunn Marie Stadskleiv, European journal of oral sciences . 2020,第1期

机译：孕妇HIV-1严重程度与龋齿：艾滋病毒1感染母亲未感染的5至7年龄儿童的观察研究，没有严重免疫抑制
3. Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge. [J] . Repits J, Sterjovski J, Badia-Martinez D, Virology . 2008,第1期

机译：晚期疾病的主要HIV-1 R5分离株显示出更高的病毒适应性，同时gp120净电荷增加。
4. Immune reconstitution in advanced HIV-1 infected patients with highly active antiretroviral therapy [C] . Taisheng Li, Aixia Wang, Zhifeng Qiu, Second workshop related to HIV/AIDS in China . 1999

机译：积极抗逆转录病毒疗法治疗晚期HIV-1感染患者的免疫重建
5. Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses [O] . Susan Zolla-Pazner, Paul T. Edlefsen, Morgane Rolland, 2014

机译：疫苗诱导的针对HIV-1 gp120第三个可变区的人源抗体对感染病毒施加免疫压力
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Short communication: severe immune suppression in patients infected with R5-tropic HIV-1 strains is associated with increased gp120 net charge at variable regions.

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