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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Fasting increases serum concentrations of bilirubin in patients receiving atazanavir: Results from a pilot study
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Short communication: Fasting increases serum concentrations of bilirubin in patients receiving atazanavir: Results from a pilot study

机译：简短交流：空腹会增加接受阿扎那韦的患者的血清胆红素浓度：一项初步研究的结果

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Unconjugated hyperbilirubinemia resulting from therapy with atazanavir is physiologically related to hyperbilirubinemia in Gilbert's syndrome (GS). In patients with GS, changes in diet have a significant impact on bilirubinemia. Our aim was to investigate whether changes in diet affect the level of serum bilirubin in patients receiving atazanavir. Thirty patients on stable therapy with ritonavir-boosted atazanavir without evidence of GS were enrolled. Hemolysis and chronic hepatitis were excluded. After a baseline period of normal intake of calories, the patients were randomized to follow a 24-h 400-calorie diet (fasting), then a 48-h period of normal calorie intake and, afterward, a 24-h period of a high-calorie diet, or the same interventions in inverse order. Serum bilirubin concentrations were measured before and after each intervention. A high adherence to the recommended diet was observed. The mean unconjugated bilirubin concentration before the high-calorie diet was 2.79±1.53 mg/dl and after such intervention it was 2.70±1.40 mg/dl. The mean difference between preintervention and postintervention was -0.08±0.69 mg/dl (p=NS). The mean unconjugated bilirubin concentration before the fasting diet was 2.31±1.23 mg/dl and it was 3.84±1.90 mg/dl after. The mean difference between prefasting and postfasting was 1.53±1.17 mg/dl (p=0.001). According to these results, short periods of fasting seem to increase the unconjugated bilirubin concentration in patients on atazanavir. A high-calorie diet did not have any impact in bilirubin probably because most patients follow similar diets in their everyday life.
机译：由阿扎那韦治疗导致的未结合的高胆红素血症在生理上与吉尔伯特综合征（GS）中的高胆红素血症有关。在GS患者中，饮食变化对胆红素血症有重要影响。我们的目的是调查饮食变化是否影响接受阿扎那韦的患者的血清胆红素水平。研究入选了30例接受ritonavir增强的阿扎那韦稳定治疗的患者，无GS证据。溶血和慢性肝炎被排除在外。在正常摄入卡路里的基线期之后，将患者随机分组，遵循24小时400卡路里饮食（禁食），然后进行48小时正常卡路里摄入，然后再进行24小时高卡路里摄入-高热量饮食，或以相反的顺序进行相同的干预。在每次干预之前和之后测量血清胆红素浓度。观察到对推荐饮食的高度坚持。高热量饮食前的平均非结合胆红素浓度为2.79±1.53 mg / dl，干预后为2.70±1.40 mg / dl。干预前和干预后的平均差为-0.08±0.69 mg / dl（p = NS）。空腹饮食前非结合胆红素的平均浓度为2.31±1.23 mg / dl，之后为3.84±1.90 mg / dl。禁食前和禁食后的平均差为1.53±1.17 mg / dl（p = 0.001）。根据这些结果，短期禁食似乎增加了阿扎那韦患者的未结合胆红素浓度。高热量饮食对胆红素没有任何影响，可能是因为大多数患者在日常生活中都遵循相似的饮食习惯。

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