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首页> 外文期刊>Biotechnology Progress >High Production System of the Antibacterial Peptide PLG-1
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High Production System of the Antibacterial Peptide PLG-1

机译：高效生产抗菌肽PLG-1

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Propionibacterium thoenii P-127 produces and releases to the growth medium antibacterial agents that can be used as natural preservatives.The concentrations of these antibacterial agents in the prowth medium are very low,and their activity can be detected only in concentrated medium,even in a biorector A simple and efficient system to produce propionicin PLG-1 with out the use of a bioreactor was investigated.Fermentation in screw-cap bottles without shaking produced antibacterial activity similar to that of fermentation in plates but in a shorter time,Sodium lactate medium (NaLa) was found to be the most supportiv for PLG-1 production compared to lactic acid bacteria media such as M-17 or beet molasses/corn.The initial concentration of the carbon source,sodium lactate agar concentration and the inital pH of the medium affected the synthesis of PLG-1 Additions of NaCl up to 1% showed no effect on the antibacterial agent production.THe optimal conditions fro production of the antibacte-rial agent were fermentation for 9 days in screw-cap bottles in modified NaLa medium (M-NaLa) containing 1% yeast extract 1% tryptic soybroth 0.9% lactic acid and 0.6% agar,adjusted to pH of 9.
机译：thoenii thoenii P-127产生并释放到生长培养基中，可用作天然防腐剂。这些抗菌剂在原始培养基中的浓度非常低，即使在浓缩培养基中也能检测到它们的活性。研究了一种不使用生物反应器即可生产丙酸PLG-1的简单有效的系统。在不摇动的螺旋盖瓶中发酵产生的抗菌活性与平板发酵相似，但在较短的时间内，乳酸钠培养基（与乳酸菌培养基（例如M-17或甜菜糖蜜/玉米）相比，NaLa）被发现对PLG-1的生产最有支持。碳源的初始浓度，乳酸钠琼脂浓度和培养基的初始pH影响了PLG-1的合成最多1％的NaCl的添加对抗菌剂的生产没有影响。将里亚尔试剂在螺帽瓶中在改良的NaLa培养基（M-NaLa）中发酵9天，该培养基包含1％酵母提取物，1％胰蛋白酶大豆，0.9％乳酸和0.6％琼脂，调节至pH为9。

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