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首页> 外文期刊>AIDS Research and Human Retroviruses >Molecular characterization of long terminal repeat sequences from brazilian human immunodeficiency virus type 1 isolates
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Molecular characterization of long terminal repeat sequences from brazilian human immunodeficiency virus type 1 isolates

机译：来自巴西人免疫缺陷病毒1型分离株的长末端重复序列的分子表征

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摘要

HIV-1 provirus activation is under control of the long terminal repeat (LTR)-5′ viral promoter region, which presents remarkable genetic variation among HIV-1 subtypes. It is possible that molecular features of the LTR contribute to the unusual profile of the subtype C epidemic in the Brazilian Southern region. To characterize the LTR of Brazilian HIV isolates, we analyzed sequences from 21 infected individuals from Porto Alegre and Salvador cities. Sequences were compared with subtype B and C reference strains from different countries. Phylogenetic analysis showed that 17 (81%) samples were subtype B and four (19%) were subtype C. Common patterns of transcription factor binding sites (TFBS) in subtypes B and C sequences were confirmed and other potential TFBS specific for subtype C were found. Brazilian subtype C sequences contained an additional NF-κB biding site, as previously described for the majority of subtype C isolates. The high level of LTR polymorphisms identified in this study might be important for viral fitness.
机译：HIV-1前病毒的激活受长末端重复（LTR）-5'病毒启动子区域的控制，该区域在HIV-1亚型之间表现出显着的遗传变异。 LTR的分子特征可能会导致巴西南部地区C型流行病的异常发生。为了表征巴西HIV分离株的LTR，我们分析了来自阿雷格里港和萨尔瓦多市的21名受感染个体的序列。将序列与来自不同国家的B和C亚型参考菌株进行比较。系统发育分析表明，有17个（81％）样品是B型，四个（19％）是C型。确定了B和C型序列中转录因子结合位点（TFBS）的常见模式，并确定了其他特定于C型的潜在TFBS。找到了。巴西C型亚型序列包含一个额外的NF-κB结合位点，如先前对大多数C型亚型分离株所述。在这项研究中确定的高水平的LTR多态性可能对病毒适应性很重要。

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