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首页> 外文期刊>AIDS Research and Human Retroviruses >Recombinant Patterns of Nine Novel HIV-1 Recombinant Strains Identified in Hebei Province, China
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Recombinant Patterns of Nine Novel HIV-1 Recombinant Strains Identified in Hebei Province, China

机译：在中国河北省鉴定的9个新型HIV-1重组菌株的重组模式

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We found cluster 1 and cluster 2 that were identified as two potential circulating recombinant forms (CRFs) by analyzing the recombinant breakpoints and phylogenetic tree. Three sequences composed of CRF01_AE, subtype C, and potential subtype B (N/A) in cluster 1 had nearly identical recombinant breakpoints, and four sequences composed of CRF01_AE and subtype B in cluster 2 possessed identical breakpoints. Demographic characteristics indicated that there were no epidemiological linkages among three subjects in cluster 1 and four subjects in cluster 2, respectively. Likewise, two unique recombinant forms (URFs) were found in this study: one URF was composed of subtype C and subtype B, and subtype B was inserted into a backbone of subtype C; another URF was composed of subtype C, subtype B, CRF01_AE, and subtype A2. It was inferred that the potential novel CRFs and URFs have spread into general populations, suggesting that the series research of novel recombinant strains will be a priority for our researches in the future.
机译：通过分析重组断点和系统发育树，我们发现了簇1和簇2被识别为两种潜在的循环重组形式（CRF）。簇1中由CRF01_AE，C亚型和潜在亚型B（N / A）组成的三个序列具有几乎相同的重组断点，簇2中由CRF01_AE和B亚型组成的四个序列具有相同的断裂点。人口统计学特征表明，聚类1中的三个受试者和聚类2中的四个受试者之间没有流行病学联系。同样，在这项研究中发现了两种独特的重组形式（URF）：一种URF由C型和B型组成，B型插入到C型主链中。另一个URF由C型，B型，CRF01_AE和A2型组成。可以推测，潜在的新型CRF和URF已传播到普通人群中，这表明对新型重组菌株的系列研究将是我们未来研究的重点。

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