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首页> 外文期刊>AIDS Research and Human Retroviruses >Rabbit retrotransposon sequences undetectable in blood donors and lymphoma patients of the Swiss HIV Cohort Study.
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Rabbit retrotransposon sequences undetectable in blood donors and lymphoma patients of the Swiss HIV Cohort Study.

机译：瑞士HIV队列研究的献血者和淋巴瘤患者无法检测到兔反转录转座子序列。

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Editor: A recent report has demonstrated that fragments of DNA present in rabbit meat are taken up from the' alimentary tract at low efficiency and can be detected transiently in human blood by sensitive amplification tests, thus extending previous reports of such horizontal DNA transfer in mice, cattle, and poultry to the human species. Alimentary DNA uptake constitutes a possible explanation for the finding of a retroviral sequence initially named human retrovirus 5 (HRV-5), but later identified as a novel rabbit retrotransposon (RERV-H), which had been detected at low copy numbers in tissues from patients with chronic inflammatory diseases,4-5 non-Hodgkin's lymphoma (NHL),6-7 and a few blood donors. It remains unclear, however, why patients with chronic inflammations or lymphoma should have a more frequent or more efficient uptake of alimentary DNA than others. Contamination of patient samples by rabbit-derived laboratory reagents such as antisera or carryover of preamplified sequences thus remains a possible alternative explanation for at least some of the positive results.
机译：编辑：最近的一份报告表明，兔肉中存在的DNA片段从消化道中吸收的效率很低，并且可以通过灵敏的扩增试验在人血中瞬时检测出来，从而扩展了以前有关小鼠中这种水平DNA转移的报道。 ，牛和家禽。消化性DNA的摄取为发现最初称为人逆转录病毒5（HRV-5）的逆转录病毒序列的发现提供了可能的解释，但后来被鉴定为新型兔逆转录转座子（RERV-H），已在组织中以低拷贝数检测到慢性炎症性疾病，4-5非霍奇金淋巴瘤（NHL），6-7和一些献血者。然而，尚不清楚为什么慢性炎症或淋巴瘤患者比其他患者更频繁或更有效地摄取消化性DNA。因此，兔源实验室试剂（例如抗血清或预扩增序列的残留物）污染患者样品仍然是至少某些阳性结果的可能替代解释。

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