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首页> 外文期刊>AIDS Research and Human Retroviruses >Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria.
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Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria.

机译：在尼日利亚乔斯接受围产期奈韦拉平预防的母亲感染的婴儿感染的婴儿中，HIV 1型逆转录酶突变的特征。

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摘要

This study was carried out to characterize HIV-1 reverse transcriptase (RT) mutations in vertically infected infants in Jos, Nigeria. DNA was extracted from peripheral blood mononuclear cells of 102 infants, aged 0 to 6 months, born to HIV-1-infected mothers who had received peripartum single-dose nevirapine prophylaxis. PCR-based diagnosis revealed that 14 infants (13.7%) were infected with HIV-1. Phylogenetic analyses of RT revealed wide viral diversity, with CRF02_AG, subtype G, subsubtype A3, CRF06_cpx, and a subtype D recombinant present in the population. Four of 13 (31%) infants had NNRTI resistance mutations--V179I (2 infants), Y181C, and V179E. Intriguingly, subtype G sequences did not have NNRTI mutations but rather carried a Q207N mutation, which may undergo negative selection under drug pressure. Our data suggest wide diversity for vertically transmitted HIV-1 viruses in Nigeria and highlight the potential significance of transmitting rare mutations in subtype G.
机译：这项研究的目的是表征尼日利亚乔斯市垂直感染婴儿的HIV-1逆转录酶（RT）突变。从102例0至6个月大的婴儿外周血单核细胞中提取DNA，这些婴儿是接受过围产期单剂量奈韦拉平预防的HIV-1感染母亲所生。基于PCR的诊断表明，有14名婴儿（13.7％）感染了HIV-1。 RT的系统发育分析表明，该种群具有广泛的病毒多样性，其中存在CRF02_AG，G亚型，A3亚型，CRF06_cpx和D亚型重组体。 13名婴儿中有4名（31％）患有NNRTI抗药性突变-V179I（2名婴儿），Y181C和V179E。有趣的是，亚型G序列没有NNRTI突变，而是带有Q207N突变，在药物压力下可能会发生负选择。我们的数据表明在尼日利亚垂直传播的HIV-1病毒具有广泛的多样性，并突出了在G型亚型中传播罕见突变的潜在意义。

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