New insights into the origin of the HIV type 1 subtype A epidemic in former soviet union's countries derived from sequence analyses of preepidemically transmitted viruses.

Thomson MM; de-Parga EV; Vinogradova A; Sierra M; Yakovlev A; Rakhmanova A; Delgado E; Casado G; Munoz M; Carmona R; Vega Y; Perez-Alvarez L; Contreras G; Medrano L; Osmanov S; Najera R

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New insights into the origin of the HIV type 1 subtype A epidemic in former soviet union's countries derived from sequence analyses of preepidemically transmitted viruses.

机译：对前苏联国家的HIV 1型亚型A流行病起源的新见解来自对前流行病毒的序列分析。

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The HIV-1 subtype A epidemic affecting injecting drug users (IDU) in former Soviet Union (FSU) countries started dramatically in Odessa, southern Ukraine, in 1995, and is caused by a variant of monophyletic origin, often designated IDU-A. We phylogenetically analyzed one near full-length genome and two partial sequences of three HIV-1 subtype A viruses collected in St. Petersburg, Russia, heterosexually transmitted in 1992-1994. The sequences branched basally to the IDU-A clade, together with eight viruses from Odessa collected in 1993, all presumably acquired heterosexually, and two viruses from the Democratic Republic of Congo. Of all other FSU sequences in databases, only those from three recently collected viruses, one from Ukraine and two from northwestern Russia, at least one of them acquired heterosexually, branched basally to the IDU-A cluster. The results indicate that the FSU IDU-A variant derives from a strain that initially propagated heterosexually in Ukraine and originated in central Africa.

机译：1995年，前苏联国家（FSU）中的影响注射吸毒者（IDU）的HIV-1亚型A流行病始于乌克兰南部的敖德萨，其起因是单一起源的变种，通常被称为IDU-A。我们在系统发育上分析了1992-1994年在俄罗斯圣彼得堡收集的三种HIV-1亚型A病毒的近全长基因组和两个部分序列。这些序列与1993年从敖德萨（Odessa）收集的八种病毒（基本上都是异性恋）以及两种来自刚果民主共和国的病毒一起基本分支到IDU-A进化枝上。在数据库中的所有其他FSU序列中，只有来自最近收集的三种病毒的序列，一种来自乌克兰，另一种来自俄罗斯西北部，其中至少一种是异性恋的，基本分支到IDU-A簇。结果表明，FSU IDU-A变体源自最初在乌克兰异性繁殖并起源于中非的菌株。

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《AIDS Research and Human Retroviruses》 |2007年第12期|共6页
作者
Thomson MM; de-Parga EV; Vinogradova A; Sierra M; Yakovlev A; Rakhmanova A; Delgado E; Casado G; Munoz M; Carmona R; Vega Y; Perez-Alvarez L; Contreras G; Medrano L; Osmanov S; Najera R;
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正文语种 eng
中图分类传染病;
关键词
Base Sequence; Congo; Epidemiology; Molecular; Genome; Viral; HIV Infections; 碱基序列; 刚果; 流行病学; 分子; 基因组; 病毒; HIV感染; 分子序列数据; 种系发生;

机译：Base Sequence;Congo;Epidemiology;Molecular;Genome;Viral;HIV Infections;碱基序列;刚果;流行病学;分子;基因组;病毒;HIV感染;分子序列数据;种系发生;

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1. New insights into the origin of the HIV type 1 subtype A epidemic in former soviet union's countries derived from sequence analyses of preepidemically transmitted viruses. [J] . Thomson MM, de-Parga EV, Vinogradova A, AIDS Research and Human Retroviruses . 2007,第12期

机译：对前苏联国家的HIV 1型亚型A流行病起源的新见解来自对前流行病毒的序列分析。
2. Can home-made injectable opiates contribute to the HIV epidemic among injection drug users in the countries of the former Soviet Union? [J] . Abdala N, Grund JP, Tolstov Y, Addiction . 2006,第5期

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3. Short communication: Molecular epidemiology of HIV type 1 in the Republic of Dagestan, Russian Federation: virtually uniform circulation of subtype A, former Soviet Union variant, with predominance of the V77I(PR) subvariant. [J] . Vinogradova A, Gafurova E, Munoz Nieto M, AIDS Research and Human Retroviruses . 2010,第4期

机译：简短交流：俄罗斯联邦达吉斯坦共和国的1型HIV分子流行病学：前苏联变种A型亚型几乎是均匀流通的，主要是V77I（PR）亚型。
4. Environmental problem analyses for cross-border territories of former Soviet Union countries [C] . N. Mavlyanova, I. Denisov, V. Lipatov International Conference on Environmental Protection and Sustainable Ecological Development . 2015

机译：前苏联国家跨境领土的环境问题分析
5. Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries [O] . Lazzat Aibekova, Brian Foley, Gonzalo Hortelano, 2012

机译：前苏联国家HIV-1亚型的分子流行病学
6. Human immunodeficiency virus type 1 (HIV-1) subtype B epidemic in Panama is mainly driven by dissemination of country-specific clades. [O] . Yaxelis Mendoza, Alexander A Martínez, Juan Castillo Mewa, 2014

机译：巴拿马的人类免疫缺陷病毒1型（HIV-1）亚型B流行病主要是由国家特定进化枝的传播推动的。
7. Environmental assessment for the purchase of Russian low enriched uranium derived from the dismantlement of nuclear weapons in the countries of the former Soviet Union [R] . 1994

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New insights into the origin of the HIV type 1 subtype A epidemic in former soviet union's countries derived from sequence analyses of preepidemically transmitted viruses.

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