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Near full-length genome sequence of a novel HIV-1 recombinant form (CRF01-AE/B) detected among men who have sex with men in jilin province, China

机译:在吉林省与男性发生性行为的男性中检测到的新型HIV-1重组形式(CRF01-AE / B)的近全长基因组序列

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摘要

We report here a novel HIV-1 recombinant form (CRF01-AE/B) detected from a comprehensive HIV-1 molecular epidemiologic study among men who have sex with men (MSM) in Jilin province of northeastern China. The near full-length genome (NFLG) analyses showed that the novel HIV-1 recombinant isolate (JL.RF07) was composed of CRF01-AE cluster 5 (northeastern China origin) and subtype B (U.S. and European origin), with six recombinant breakpoints observed in the pol, vif, tat, rev, and env gene regions. To the best of our knowledge, this is the first detection of a novel HIV-1 recombinant form (CRF01-AE/B) in Jilin, which may indicate an active transmission network of HIV-1 infection among MSM in the region. Further studies of the molecular epidemiology of the HIV-1 epidemic among MSM in northeastern China are necessary to gain a fuller understanding of the transmission network and potential public health impact of HIV-1 among MSM in this region.
机译:我们在这里报告了一种新型的HIV-1重组形式(CRF01-AE / B),这是从一项全面的HIV-1分子流行病学研究中在中国东北吉林省的男男性行为者(MSM)中检测到的。近全长基因组(NFLG)分析表明,新型HIV-1重组分离株(JL.RF07)由CRF01-AE簇5(中国东北起源)和B亚型(美国和欧洲起源)组成,具有六个重组体在pol,vif,tat,rev和env基因区域中观察到断点。据我们所知,这是吉林省首次检测到新型HIV-1重组形式(CRF01-AE / B),这可能表明该地区MSM之间HIV-1感染的活跃传播网络。为了更全面地了解该地区MSM中HIV-1的传播网络和潜在的公共卫生影响,有必要对中国东北MSM中HIV-1流行的分子流行病学进行进一步研究。

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