...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS Research and Human Retroviruses >Brain magnetic resonance imaging screening is not useful for HIV-1-infected patients without neurological symptoms
【24h】

Brain magnetic resonance imaging screening is not useful for HIV-1-infected patients without neurological symptoms

机译：脑磁共振成像筛查对无神经系统症状的HIV-1感染患者无用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We investigated the diagnostic usefulness of brain magnetic resonance imaging (MRI) screening in HIV-1-infected patients without neurological symptoms in detecting intracranial diseases at early stages. In this retrospective analysis, the study patients were HIV-1-infected patients who underwent brain MRI scan in clinical practice between 2001 and 2013. We excluded patients with MRI for (1) follow-up examination for prediagnosed intracranial diseases, (2) cancer staging, (3) screening mycobacterium/bacteria/fungi disease proliferation in the brain, and (4) evaluation for meningitis/encephalitis. The study patients (n=485) were classified into two groups: those who underwent brain MRI scan without any neurological symptoms/signs (asymptomatic patients, n=158) and those who underwent MRI due to such symptoms (symptomatic patients, n=327). Asymptomatic patients had lower CD4 counts than symptomatic patients (median 78 versus 241/μl). Intracranial diseases were detected in three (2%) of the asymptomatic patients [two toxoplasmosis and one progressive multifocal leukoencephalopathy (PML)] compared to 58 (19%) of the symptomatic patients (the χ2 test, p0.01). The latter included toxoplasmosis (n=10), PML (n=7), cytomegalovirus encephalitis (n=3), primary central nervous system lymphoma (n=3), cryptococcoma/meningitis (n=3), and HIV-associated dementia (n=17). Among symptomatic patients, intracranial diseases were common in those with slurred speech (3/6, 50%), seizure (4/10, 40%), eyesight/vision abnormality (5/16, 31%), altered mental status (8/31, 26%), and hemiplegiaumbness (13/50, 26%). For patients with CD4 count 200/μl, intracranial diseases were detected in only 3 (3%) of 144 asymptomatic patients, compared with 46 (32%) of 113 symptomatic patients (p0.01). Brain MRI screening for HIV-1-infected patients without neurological symptoms is of little value.
机译：我们调查了在没有神经系统症状的HIV-1感染患者中进行脑磁共振成像（MRI）筛查对早期发现颅内疾病的诊断有用性。在此回顾性分析中，研究对象为2001年至2013年间在临床实践中接受过脑部MRI扫描的HIV-1感染患者。我们排除了MRI患者进行（1）颅内疾病预后的随访检查，（2）癌症分期，（3）筛选脑中的分枝杆菌/细菌/真菌疾病增殖，以及（4）评估脑膜炎/脑炎。研究患者（n = 485）分为两组：接受无任何神经系统症状/体征的脑部MRI扫描的患者（无症状患者，n = 158）和由于此类症状而进行MRI的患者（有症状患者，n = 327） ）。无症状患者的CD4计数低于有症状患者（中位数为78对241 /μl）。在三名（2％）无症状患者中发现了颅内疾病[2弓形虫病和一例进行性多灶性白质脑病（PML）]，而有症状患者中有58例（19％）被发现（χ2检验，p <0.01）。后者包括弓形虫病（n = 10），PML（n = 7），巨细胞病毒性脑炎（n = 3），原发性中枢神经系统淋巴瘤（n = 3），隐球菌/脑膜炎（n = 3）和与HIV相关的痴呆（n = 17）。在有症状的患者中，颅内疾病常见于言语不清（3 / 6，50％），癫痫发作（4 / 10，40％），视力/视力异常（5 / 16，31％），精神状态改变（8）的患者。 / 31，26％）和偏瘫/麻木（13/50，26％）。对于CD4计数<200 /μl的患者，在144例无症状患者中仅3例（3％）检出了颅内疾病，而113例有症状患者中46例（32％）被检出（p <0.01）。对于没有神经系统症状的HIV-1感染患者进行脑MRI筛查几乎没有价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号