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首页> 外文期刊>AIDS Research and Human Retroviruses >Diversity of human immunodeficiency virus type 1 subtypes in Kagera and Kilimanjaro regions, Tanzania.
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Diversity of human immunodeficiency virus type 1 subtypes in Kagera and Kilimanjaro regions, Tanzania.

机译：坦桑尼亚的Kagera和Kilimanjaro地区的人类免疫缺陷病毒1型亚型的多样性。

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摘要

A strategy to prevent the spread of HIV-1 worldwide is complicated by the high genetic diversity of the virus. To gain a better understanding of the HIV-1 genetic diversity in Tanzania, a molecular epidemiological investigation was conducted in Kagera and Kilimanjaro regions. While several studies have addressed HIV-1 subtypes in Tanzania, this is the first study to describe the virus subtypes circulating in Kagera. The Kagera region is the epicenter of the HIV-1 epidemic in Africa, and it was therefore of interest to compare the prevalence of HIV subtypes in this region and Kilimanjaro. Blood samples were obtained from 246 HIV-1-infected pregnant women attending antenatal clinics. Plasma HIV-1 RNA was extracted, amplified, and sequenced in the env C2V3 and/or pol regions from 209 samples. Based on the analysis of env C2V3 and pol sequences, 47.4% had concordant subtypes, 19.1% were discordant indicating recombination, and for 33.5% sequences were obtained for only one region. The distribution HIV-1 subtypes based on the phylogenetic analysis of paired env C2V3/ pol sequences in Kagera region was A/A (27.8%), C/C (29.6%), D/D (16.7%), and unique recombinant forms (25.9%), and in Kilimanjaro region was A/A (32.9%), C/C (25.9%), D/D (10.6%), CRF10_CD (1.2%), and unique recombinant forms (29.4%). The env C2V3 subsubtype A2 and env C2V3/pol CRF10_CD were also observed indicating that these recombinants are circulating in Tanzania. The high diversity of HIV-1 subtypes and the high prevalence of recombinants demonstrated in this study necessitate expanded and continuous monitoring of the epidemic in Tanzania. The trend may have implications for current national control strategies against the HIV-1 epidemic.
机译：该病毒的高度遗传多样性使预防HIV-1在世界范围内传播的策略变得复杂。为了更好地了解坦桑尼亚的HIV-1遗传多样性，在Kagera和Kilimanjaro地区进行了分子流行病学调查。尽管有几项研究针对坦桑尼亚的HIV-1亚型，但这是第一项描述在Kagera中传播的病毒亚型的研究。 Kagera地区是非洲HIV-1流行的中心，因此比较该地区和乞力马扎罗山的HIV亚型的患病率很有意义。从在产前诊所就诊的246名感染HIV-1的孕妇中获取血液样本。在209个样本的env C2V3和/或pol区域提取，扩增和测序血浆HIV-1 RNA。根据对env C2V3和pol序列的分析，47.4％的序列具有一致的亚型，19.1％的序列不一致表明重组，仅在一个区域获得了33.5％的序列。根据对配对的env C2V3 / pol序列在Kagera地区进行的系统发育分析，HIV-1亚型的分布为A / A（27.8％），C / C（29.6％），D / D（16.7％）和独特的重组形式。 （25.9％），在乞力马扎罗地区是A / A（32.9％），C / C（25.9％），D / D（10.6％），CRF10_CD（1.2％）和独特的重组形式（29.4％）。还观察到env C2V3亚型A2和env C2V3 / pol CRF10_CD，表明这些重组体在坦桑尼亚流通。这项研究表明，HIV-1亚型的高度多样性和重组体的高流行使得有必要扩大和持续监测坦桑尼亚的流行病。这种趋势可能会影响当前针对HIV-1流行的国家控制策略。

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