Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients

Wang Ting; Green Linden A.; Gupta Samir K.; Amet Tohti; Byrd Daniel J.; Yu Qigui; Twigg Homer L.; Clauss Matthias

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Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients

机译：HIV患者外周血单个核细胞中检测到的细胞内Nef

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We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.

机译：我们在此报告了一项新发现，即HIV阴性因子（Nef）蛋白存在于未接受抗逆转录病毒治疗（ART）的病毒性感染HIV的患者以及接受病毒学抑制性ART的患者的相当数量的外周血单核细胞（PBMC）中，虽然程度较小。有趣的是，这些Nef阳性PBMC主要是未感染的旁观者细胞。这些结果可能解释了艾滋病毒患者的全身病理，甚至是接受抗逆转录病毒疗法的患者。

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《AIDS Research and Human Retroviruses》 |2015年第2期|共4页
作者
Wang Ting; Green Linden A.; Gupta Samir K.; Amet Tohti; Byrd Daniel J.; Yu Qigui; Twigg Homer L.; Clauss Matthias;
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正文语种 eng
中图分类传染病;
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1. Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients [J] . Wang Ting, Green Linden A., Gupta Samir K., AIDS Research and Human Retroviruses . 2015,第2期

机译：HIV患者外周血单个核细胞中检测到的细胞内Nef
2. Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of HIV patients by a coulter counter to determine intracellular drug concentrations. [J] . Simiele M, DAvolio A, Baietto L, Antimicrobial agents and chemotherapy. . 2011,第6期

机译：通过库尔特计数器评估HIV患者外周血单个核细胞的平均小体体积，以确定细胞内药物浓度。
3. Plasma and intracellular (peripheral blood mononuclear cells) pharmacokinetics of once-daily raltegravir (800 milligrams) in HIV-infected patients. [J] . Molto J, Valle M, Back D, Antimicrobial agents and chemotherapy. . 2011,第1期

机译：在感染HIV的患者中，每天一次的raltegravir（800毫克）的血浆和细胞内（外周血单核细胞）药代动力学。
4. The preclinical evaluation of anti-HIV compounds in the HIV-infected SCID mouse reconstituted with human peripheral blood mononuclear cells [C] . Michael Ussery Second workshop related to HIV/AIDS in China . 1999

机译：在用人外周血单核细胞重建的被HIV感染的SCID小鼠中抗HIV化合物的临床前评估
5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

机译：HIV-1感染儿童血清中的IgE抗HIV-1抑制了HIV-1的体外产生，IgE介导了对HIV-1血清反应阳性患者表达HIV-1的淋巴瘤细胞和外周血单核细胞的细胞毒性
6. Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients [O] . Ting Wang, Linden A. Green, Samir K. Gupta, -1

机译：HIV患者外周血单个核细胞中检测到的细胞内Nef
7. Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients [O] . Wang, Ting, Green, Linden A., Gupta, Samir K., 2014

机译：HIV患者外周血单个核细胞中检测到的细胞内Nef

Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients

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