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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
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Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.

机译：简短交流：进行性和非进行性小儿HIV 1型感染中的CD8（+）T细胞多功能性概况。

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摘要

Pediatric HIV-1 infection is characterized by rapid disease progression and without antiretroviral therapy (ART), more than 50% of infected children die by the age of 2 years. However, a small subset of infected children progresses slowly to disease in the absence of ART. This study aimed to identify functional characteristics of HIV-1-specific T cell responses that distinguish children with rapid and slow disease progression. Fifteen perinatally HIV-infected children (eight rapid and seven slow progressors) were longitudinally studied to monitor T cell polyfunctionality. HIV-1-specific interferon (IFN)-gamma(+) CD8(+) T cell responses gradually increased over time but did not differ between slow and rapid progressors. However, polyfunctional HIV-1-specific CD8(+) T cell responses, as assessed by the expression of four functions (IFN-gamma, CD107a, TNF-alpha, MIP-1beta), were higher in slow compared to rapid progressors (p=0.05) early in infection, and was associated with slower subsequent disease progression. These data suggest that the quality of the HIV-specific CD8(+) T cell response is associated with the control of disease in children as has been shown in adult infection.
机译：小儿HIV-1感染的特征是疾病进展迅速，并且没有抗逆转录病毒疗法（ART），到2岁时，有超过50％的感染儿童死亡。但是，一小部分受感染的儿童在没有抗病毒治疗的情况下进展缓慢。这项研究旨在确定HIV-1特异性T细胞反应的功能特征，以区分疾病进展快和慢的儿童。纵向研究了十五名围生期感染HIV的儿童（八名快速进展者和七名缓慢进展者）以监测T细胞的多功能性。 HIV-1特异性干扰素（IFN）-γ（+）CD8（+）T细胞反应随时间逐渐增加，但在慢速进展者和快速进展者之间没有区别。但是，通过四种功能（IFN-γ，CD107a，TNF-α，MIP-1beta）的表达评估，多功能HIV-1特异性CD8（+）T细胞应答与快速进展者相比，在慢速情况下更高（p = 0.05）处于感染早期，并且与随后的疾病进展较慢有关。这些数据表明，成人感染已表明，HIV特异性CD8（+）T细胞反应的质量与儿童疾病的控制有关。

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