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首页> 外文期刊>AIDS Research and Human Retroviruses >A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults.
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A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults.

机译：前瞻性队列研究艾滋病毒感染成人的牙周疾病指标和心血管疾病标志。

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The determinants of HIV-associated cardiovascular disease (CVD) are not well understood. Periodontal disease (PD) has been linked to CVD but this connection has not been examined in HIV infection. We followed a cohort of HIV-infected adults to ascertain whether PD was associated with carotid artery intima media thickness (IMT) and brachial artery flow-mediated dilation (FMD). We performed a longitudinal observational study of HIV-infected adults on HAART for <2 years with no known heart disease. PD was characterized clinically and microbiologically. Cardiovascular disease was assessed by IMT/FMD. Linear mixed models assessed cross-sectional and longitudinal associations between PD and FMD/IMT. Forty three HIV(+) adults completed a median of 24 (6-44) months on the study. Defining delta to be the change in a variable between baseline and a follow-up time, longitudinally, on average and after adjusting for change in time, CVD-specific and HIV-specific potential confounding covariates, a 1-log(10) increase in delta Porphyromonas gingivalis was associated with a 0.013 mm increase in delta IMT (95% CI: 0.0006-0.0262; p=0.04). After adjusting for the same potential confounding covariates, a 10% increase in delta gingival recession was associated with a 2.3% increase in delta FMD (95% CI: 0.4-4.2; p=0.03). In a cohort of HIV-infected adults, an increase in subgingival Porphyromonas gingivalis, a known periodontal pathogen, was significantly associated with longitudinal increases in IMT, while increased gingival recession, which herein may represent PD resolution, was significantly associated with longitudinal improvement in FMD. In the context of HIV infection, PD may contribute to CVD risk. Intervention studies treating PD may help clarify this association.
机译：HIV相关的心血管疾病（CVD）的决定因素还没有被很好地理解。牙周疾病（PD）与CVD相关，但尚未在HIV感染中检查这种联系。我们追踪了一批感染了HIV的成人，以确定PD是否与颈动脉内膜中层厚度（IMT）和肱动脉血流介导的扩张（FMD）相关。我们对HAART感染HIV的成年人进行了<2年的纵向观察研究，没有已知的心脏病。 PD的临床和微生物学特征。通过IMT / FMD评估心血管疾病。线性混合模型评估了PD和FMD / IMT之间的横截面和纵向关联。在该研究中，四十三名HIV（+）成人完成了平均24（6-44）个月的时间。将增量定义为纵向和平均时间之间的基线和随访时间之间的变量变化，并在对时间变化，CVD特异性和HIV特异性潜在混杂变量进行校正后，其1-log（10）增加牙龈卟啉单胞菌三角洲与三角洲IMT增加0.013毫米相关（95％CI：0.0006-0.0262; p = 0.04）。在调整了相同的潜在混杂变量后，牙龈退缩的增加10％与FMD的增加2.3％有关（95％CI：0.4-4.2; p = 0.03）。在一群受HIV感染的成年人中，牙龈下卟啉单胞菌（一种已知的牙周病原体）的增加与IMT的纵向增加显着相关，而牙龈退缩的增加（此处可能代表PD消退）与FMD的纵向改善显着相关。 。在HIV感染的情况下，PD可能导致CVD风险。治疗PD的干预研究可能有助于阐明这种关联。

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