((13)C)Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients.

Sternfeld T; Lorenz A; Schmid

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((13)C)Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients.

机译：（（13）C）甲硫氨酸呼气试验可作为HIV感染患者肝线粒体功能的标志物。

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Metabolic disturbances such as dyslipidemia, lipodystrophy syndrome, visceral obesity, hyperlactatemia, diabetes mellitus, and hepatic steatosis have been recognized as serious complications in long-term antiretroviral-treated HIV-infected patients. The oxidative capacity of liver mitochondria plays a central role in their pathogenesis and can be analyzed using the [(13)C]methionine breath test. We analyzed hepatic mitochondrial function using the [(13)C]methionine breath test in antiretrovirally treated and untreated HIV-infected patients as well as HIV-negative controls. Patients with hepatic steatosis, hypertriglyceridemia, lipohypertrophy, and older age showed reduced methionine metabolism. Hepatic mitochondrial function is impaired in antiretroviral-treated HIV-infected patients with disturbances of lipid metabolism.

机译：在长期接受抗逆转录病毒治疗的HIV感染患者中，代谢异常（例如血脂异常，脂肪营养不良综合征，内脏肥胖，高乳酸血症，糖尿病和肝脂肪变性）被认为是严重的并发症。肝线粒体的氧化能力在其发病机理中起着核心作用，可以使用[（13）C]蛋氨酸呼气试验进行分析。我们使用[（13）C]蛋氨酸呼气试验分析了抗逆转录病毒治疗和未治疗的HIV感染患者以及HIV阴性对照的肝线粒体功能。患有肝脂肪变性，高甘油三酯血症，脂肪过多症和年龄较大的患者，蛋氨酸代谢降低。抗逆转录病毒治疗的HIV感染者的脂质代谢紊乱会损害肝线粒体功能。

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《AIDS Research and Human Retroviruses》 |2009年第12期|共6页
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Sternfeld T; Lorenz A; Schmid;
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1. ((13)C)Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients. [J] . Sternfeld T, Lorenz A, Schmid AIDS Research and Human Retroviruses . 2009,第12期

机译：（（13）C）甲硫氨酸呼气试验可作为HIV感染患者肝线粒体功能的标志物。
2. 13C-methionine breath test detects distinct hepatic mitochondrial dysfunction in HIV-infected patients with normal serum lactate. [J] . Banasch M, Goetze O, Hollborn I, JAIDS: Journal of acquired immune deficiency syndromes . 2005,第2期

机译：13C-蛋氨酸呼气试验可检测出具有正常血清乳酸的HIV感染患者的明显肝线粒体功能障碍。
3. The Non-invasive (13)C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis. [J] . Banasch M, Ellrichmann M, Tannapfel A, European journal of medical research. . 2011,第6期

机译：非侵入性（13）C-蛋氨酸呼气试验可检测肝线粒体功能障碍，作为非酒精性脂肪性肝炎疾病活动的标志。
4. Mathematical analysis of ~(13)CO_2-expiration curves from human breath tests using 1-~(13)C-amino acids as oral substrate [C] . V.V.A.M. Schreurs, K. Krawielitzki Joint Symposium on Energy and Protein Metabolism and Nutrition . 2003

机译：〜（13）CO_2折架曲线的数学分析使用1-（13）C - 氨基酸作为口服底物
5. Correlates of neuropsychological functioning and associations with therapeutic alliance in HIV-infected and HIV-uninfected opiate-dependent patients. [D] . Applebaum, Allison J. 2011

机译：HIV感染和未感染HIV的阿片依赖患者的神经心理学功能和与治疗联盟的关联。
6. The non-invasive 13C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis [O] . M Banasch, M Ellrichmann, A Tannapfel, 2011

机译：非侵入性13C-蛋氨酸呼气试验可检测肝线粒体功能障碍作为非酒精性脂肪性肝炎疾病活动的标志
7. The non-invasive ¹³C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis [O] . Banasch M, Ellrichmann M, Tannapfel A, 2012

机译：非侵入性^{13 C-蛋氨酸呼气试验检测肝线粒体功能障碍是非酒精性脂肪性肝炎疾病活动的标志}

((13)C)Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients.

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