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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines
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Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines

机译：用于食品和草药中吡咯烷生物碱的毒理风险评估的临时相对效力因素

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摘要

Pyrrolizidine alkaloids (PAs) are among the most potent natural toxins occurring in a broad spectrum of plant species from various families. Recently, findings of considerable contamination of teas/herbal infusions prepared from non-PA plants have been reported. These are obviously due to cross-contamination with minor amounts of PA plants and can affect both food and herbal medicines. Another source of human exposure is honey collected from PA plants. These findings illustrate the requirement for a comprehensive risk assessment of PAs, hampered by the enormous number of different PA congeners occurring in nature. Up to now, risk assessment is based on the carcinogenicity of certain PAs after chronic application to rats using the sum of detected PAs as dose metric. Because of the well-documented large structure-dependent differences between sub-groups of PA congeners with respect to their genotoxicity and (cyto) toxicity, however, this procedure is inadequate.
机译：吡咯啉氨基生物碱（PAS）是来自各种家庭的广谱植物种类中的最有效的天然毒素之一。 最近，已经报道了从非PA植物制备的茶叶/草药输注的大幅污染的结果。 这些显然是由于具有少量PA植物的交叉污染，并且可以影响食物和草药。 人类暴露的另一个来源是从PA植物收集的蜂蜜。 这些发现说明了对PA的综合风险评估的要求，受到自然界发生的巨大不同PA同一步者的阻碍。 到目前为止，风险评估基于某些PAS在慢性施用到大鼠的致癌性，使用检测到的PAS作为剂量度量。 由于良好地记录了PA与遗传毒性和（CYTO）毒性的PA与（CYTO）毒性的副组之间的大的结构依赖性差异不足。

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