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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Geometry of carbon nanotubes and mechanisms of phagocytosis and toxic effects
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Geometry of carbon nanotubes and mechanisms of phagocytosis and toxic effects

机译：碳纳米管的几何和吞噬作用机制和毒性作用

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摘要

A review of in vivo and in vitro toxicological studies of the potential toxic effects of carbon nanotubes is presented along with the analysis of experimental data and a hypothesis about the nanotube-asbestos similarity. Developments of the structure-activity paradigm have been reviewed along with the size effects and the classification of carbon nanotubes into eleven distinct classes (e.g., the high aspect ratio nanotubes, thick multi-wall nanotubes and short nanotubes). Scaling analysis of similarities between different classes of carbon nanotubes and asbestos fibers in the context of their potential toxicity and the efficiency of phagocytosis has been reviewed. The potential toxic effects of carbon nanotubes have been characterized by their normalized length, their aspect ratio and other parameters related to their inhalability, engulfment by macrophages and the effectiveness of phagocytosis. Geometric scaling parameters and the classification of carbon nanotubes are used to develop an updated parametric map for the extrapolation of the potential toxic effects resulting from the inhalation of long and short carbon nanotubes. An updated parametric map has been applied to the evaluation of the efficiency of phagocytosis involving distinct classes of carbon nanotubes. A critical value of an important nondimensional parameter characterizing the efficiency of phagocytosis for different nanotubes is presented along with its macrophage-based normalization. The present evaluation of the potential toxicological effects of the high aspect ratio carbon nanotubes is found to be in the agreement with other available studies and earlier scaling analyses. (C) 2017 Elsevier B.V. All rights reserved.
机译：对碳纳米管潜在毒性作用的体内和体外毒理学研究的综述随着实验数据的分析以及关于纳米管 - 石棉相似性的假设。已经审查了结构 - 活性范式的发展以及尺寸效应和碳纳米管分成11个不同的类（例如，高纵横比纳米管，厚的多壁纳米管和短纳米管）的尺寸效应和分类。综述了各种碳纳米管与石棉纤维在其潜在毒性背景下的缩放分析及吞噬作用效率。碳纳米管的潜在毒性效应的特征在于它们的标准化长度，它们的纵横比和与其吸入性，巨噬细胞吞噬以及吞噬作用的有效性相关的其他参数。几何缩放参数和碳纳米管的分类用于开发更新的参数图，用于引起长短碳纳米管引起的潜在毒性效应的外推。已应用更新的参数图已应用于评估涉及不同类别的碳纳米管的吞噬作用效率。表征了表征不同纳米管的吞噬作用效率的重要非潜能参数的临界值及其基于巨噬细胞的标准化。本发明的高纵横比碳纳米管的潜在毒理学效应的评价存在于与其他可用研究和早期的缩放分析中的协议中。 （c）2017 Elsevier B.v.保留所有权利。

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