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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: Longitudinal Changes in Peripheral Blood NK Cells During the First Year of HIV-1 Infection in CD4(Low) and CD4(High) Patient Groups
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Short Communication: Longitudinal Changes in Peripheral Blood NK Cells During the First Year of HIV-1 Infection in CD4(Low) and CD4(High) Patient Groups

机译：简短交流：CD4（低）和CD4（高）患者组在HIV-1感染的第一年期间外周血NK细胞的纵向变化

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摘要

Natural killer (NK) cells may modulate the pathogenesis of primary HIV-1 infection. However, the relationship between the number and function of NK cells during an acute HIV-1 infection and HIV-1 disease progression remains to be elucidated. In this study, we enrolled two distinct patient groups. One group progressed to where their CD4 cell counts fell below 200 cells/mu l within 2 years (CD4(Low) group), while the CD4 cell counts of the other group remained above 500 cells/mu l for over 2 years (CD4(High) group). We compared the number and function of NK cells during the first year of HIV-1 infection between the two distinct groups. We found that the number of total NK cells and the number of cells in the CD56(dim)CD16(pos) subset rapidly decreased in both groups during early HIV-1 infection. The absolute number of total NK cells and CD56(dim)CD16(pos) NK cells was significantly higher in the CD4(High) group when compared to the CD4(Low) group during the first month of infection. No significant difference between the numbers of CD56(bright)CD16(neg) NK cells of the two groups was observed. However, more CD56(neg)CD16(pos) NK cells were found in the CD4(Low) group than in the CD4(High) group. We also found that NK cell function increased within the first 3 months of HIV-1 infection in the CD4(High) group and then exhibited a decreasing trend. However, in the CD4(Low) group, NK cell function did not increase significantly within the first 3 months of HIV-1 infection but then gradually increased. We concluded, therefore, that robust NK functioning cells that are present during an acute HIV-1 infection might be beneficial in controlling HIV-1 disease progression.
机译：自然杀伤（NK）细胞可能会调节原发性HIV-1感染的发病机制。但是，急性HIV-1感染期间NK细胞的数量和功能与HIV-1疾病进展之间的关系仍有待阐明。在这项研究中，我们招募了两个不同的患者组。一组进展到2年内其CD4细胞计数降至200细胞/μl以下（CD4（低）组），而另一组CD4细胞计数在2年以上仍保持在500细胞/μl以上（CD4（高）组）。我们比较了两个不同组之间在HIV-1感染的第一年中NK细胞的数量和功能。我们发现，在早期HIV-1感染期间，两组的总NK细胞数量和CD56（dim）CD16（pos）亚群中的细胞数量迅速减少。在感染的第一个月中，CD4（高）组的总NK细胞和CD56（dim）CD16（pos）NK细胞的绝对数量显着高于CD4（低）组。两组的CD56（亮）CD16（neg）NK细胞数量之间没有观察到显着差异。但是，在CD4（低）组中发现的CD56（neg）CD16（pos）NK细胞比CD4（高）组中的更多。我们还发现，CD4（高）组在HIV-1感染的前三个月内，NK细胞功能增强，然后呈现下降趋势。但是，在CD4（Low）组中，NK细胞功能在HIV-1感染的前3个月内并未显着增加，但随后逐渐增加。因此，我们得出的结论是，在急性HIV-1感染期间存在的强大的NK功能细胞可能对控制HIV-1疾病的进展有益。

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