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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
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Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil

机译：简短交流：重新评估在巴西传播的HIV-1 CRF02_AG血统的起源

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摘要

HIV-1 CRF02_AG is responsible for at least 8% of the HIV-1 infections worldwide and is distributed mainly in West Africa. CRF02_AG has recently been reported in countries where it is not native, including Brazil. In a previous study including 10 CRF02_AG Brazilian samples, we found at least four independent introductions and two autochthonous transmission networks of this clade in Brazil. As more CRF02_AG samples have been identified in Brazil, we performed a new phylogeographic analysis using a larger dataset than before. A total of 20 Brazilian (18 from Rio de Janeiro and two from SAo Paulo) and 1,485 African HIV-1 CRF02_AG pol sequences were analyzed using maximum likelihood (ML). The ML tree showed that the Brazilian sequences were distributed in five different lineages. The Bayesian phylogeographic analysis of the Brazilian and their most closely related African sequences (n=212) placed the origin of all Brazilian lineages in West Africa, probably Ghana, Senegal, and Nigeria. Two monophyletic clades were identified, comprising only sequences from Rio de Janeiro, and their date of origin was estimated at around 1985 (95% highest posterior density: 1979-1992). These results support the existence of at least five independent introductions of the CRF02_AG lineage from West Africa into Brazil and further indicate that at least two of these lineages have been locally disseminated in the Rio de Janeiro state over the past 30 years.
机译：HIV-1 CRF02_AG至少占全世界HIV-1感染的8％，主要分布在西非。最近在包括巴西在内的非本地国家报告了CRF02_AG。在先前的研究中，包括10个CRF02_AG巴西样本，我们在巴西发现了至少四个独立的引种和两个该分支的自生传播网络。随着在巴西发现更多的CRF02_AG样品，我们使用了比以前更大的数据集进行了新的系统地理分析。使用最大似然（ML）分析了总共20个巴西人（18个来自里约热内卢，两个来自圣保罗）和1,485个非洲HIV-1 CRF02_AG pol序列。 ML树表明巴西序列分布在五个不同谱系中。对巴西及其最密切相关的非洲序列（n = 212）的贝叶斯系统地理分析使西非所有巴西谱系的起源都可能在加纳，塞内加尔和尼日利亚。确定了两个单系进化枝，仅包含里约热内卢的序列，其起源日期估计在1985年左右（后验最高密度的95％：1979-1992年）。这些结果支持至少有五种独立的CRF02_AG血统从西非传入巴西，并且进一步表明，在过去的30年中，至少有两个血统已经在里约热内卢州本地传播。

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