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首页> 外文期刊>Transplant immunology >Donor IL-6 deficiency evidently reduces memory T cell responses in sensitized transplant recipients
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Donor IL-6 deficiency evidently reduces memory T cell responses in sensitized transplant recipients

机译：供体IL-6缺乏明显减少了敏化移植受体中的记忆T细胞应答

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摘要

BackgroundResistance of tolerance induction in sensitized transplantation is mainly caused by generation of memory T cells. It is unknown whether alteration of graft niche such as level of pro-inflammatory cytokines can affect generation of memory T cells. MethodsIL-6 deficient or wild-type (WT) C57BL/6 heart grafts were transplanted into pre-sensitized wild-type BALB/c recipients. Frequencies of memory T cells in the peripheral blood, grafts, and spleen were evaluated. ResultsWe revealed that deficiency of donor IL-6 could significant prolong sensitized allograft survival. Compared with counterpart of WT group, frequency of effector memory CD4?+?T cells (CD4?+?CD44?+?CD62L-) in the peripheral blood was significantly lower in the IL-6 KO group (p?=?.026) at day 3 post-transplantation. Frequency of effector memory CD8?+?T cells (CD8?+?CD44?+?CD62L-) in the peripheral blood was significantly lower in the IL-6 KO group (p?
机译：敏化移植中耐受性诱导的背景主要是由Memory T细胞产生引起的。尚不清楚是否诸如促炎细胞因子的水平的移植物利用的变化可以影响内存T细胞的产生。方法将缺陷或野生型（WT）C57BL / 6心脏移植物移植到预敏化的野生型BALB / C受体中。评估了外周血，移植物和脾脏中记忆T细胞的频率。结果揭示了供体IL-6的缺乏可以显着的延长致敏的同种异体移植物存活。与WT组的对应物相比，在IL-6 KO组中，效应记忆CD4？+ΔT细胞（CD4？+？CD44？CD62L-）在外周血中显着降低（P？= 026 ）第3天移植后。效应记忆CD8的频率cd8？+Δt细胞（CD8？+？CD44？CD644？CD621-）在移植后第3天在第3天的IL-6 KO组（P？<+ 0001）中显着降低与WT组相比。这些组之间发现中央记忆T细胞的显着差异。组织学证明了供体促炎细胞因子IL-6（IL-6 KO组）的缺乏保存的心脏结构，具有轻度浸润的淋巴细胞，而野生型供体（对照组）在移植物的心肌纤维中引起明显的淋巴细胞浸润心脏结构的破坏。结论供体移植剂的促炎IL-6可有效延长致敏的同种异体移植存活，这是由外周记忆T细胞而不是中央记忆T细胞的显着降低引起的。这种靶向IL-6信号传导途径的揭示机制可以为预防敏化移植受体的异种移植抑制剂提供新颖的洞察力。

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  • 来源
    《Transplant immunology》 |2018年第2018期|共7页
  • 作者

    Juntao Chen; Chen Liu; Baoqing Liu; Deqiang Kong; Liang Wen; Weihua Gong;

  • 作者单位

    Department of Surgery Second Affiliated Hospital of School of Medicine Zhejiang University;

    Department of Surgery Second Affiliated Hospital of School of Medicine Zhejiang University;

    Department of Surgery Second Affiliated Hospital of School of Medicine Zhejiang University;

    Department of Surgery Second Affiliated Hospital of School of Medicine Zhejiang University;

    Department of Surgery Second Affiliated Hospital of School of Medicine Zhejiang University;

    Department of Surgery Second Affiliated Hospital of School of Medicine Zhejiang University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 器官移植术;
  • 关键词

    Interleukin-6; Memory T CELLS; Transplant tolerance;

    机译：白细胞介素-6;记忆T细胞;移植耐受性;

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