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Epidemiology of donors and recipients: lessons from the SCANDAT database

机译：捐助者和接受者的流行病学：斯堪的州数据库的课程

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摘要

With the development of several 'vein-to-vein' databases, which capture data on the entire donor-recipient continuum and link this data to health outcomes, there has been an increasing number of studies investigating the health effects of all aspects of the practice of transfusion medicine. The Scandinavian Donations and Transfusions (SCANDAT) database is one of several such databases, which includes all electronically available data on blood donors, donations and transfusions since the late 1960s in Sweden and the early 1980s in Denmark. The SCANDAT database has been used to characterise disease occurrence among blood donors and transfused patients, as well as to investigate possible health effects of blood donations, aspects of transfusion care and possible transfusion transmission of disease. Recent publications include studies on recipient mortality associated with the storage lesion, studies on the effects of donor demographics on patient mortality and health effects of frequent blood donation. Although this research approach is clearly very powerful, the appropriate analysis of such real-world data is complex and requires close methodological attention. The purpose of this review is to present some of the research conducted within the SCANDAT collaboration. We hope more international collaboration may help improve our understanding of the important remaining questions about donor and recipient health.
机译：随着几个'静脉 - 静脉'数据库的发展，捕获整个捐助者 - 受援人员的数据，并将这些数据链接到健康结果，越来越多的研究调查了实践各方面的健康影响输血医学。斯堪的纳维亚捐赠和输血（Scandat）数据库是几个这样的数据库之一，包括自瑞典20世纪60年代末及其20世纪60年代后期以来的献血者，捐赠和输血的所有电子可用数据和20世纪80年代初。 Scandat数据库已用于表征血液供体和转染患者的疾病发生，以及调查献血的可能的健康影响，输血护理的各个方面以及可能的输血传播。最近的出版物包括关于与储存病变相关的受体死亡的研究，捐助人口统计学对患者死亡率和频繁献血的健康影响的研究。虽然这种研究方法显然是非常强大的，但对这种真实世界的适当分析是复杂的，需要密切的方法注意。本次审查的目的是展示在Scandat协作内进行的一些研究。我们希望更多的国际合作可能有助于提高我们对捐助者和受援人士健康的重要剩余问题的理解。

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