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首页> 外文期刊>Transfusion medicine >Monitoring of prenatal patients using a combined antibody titre for Rh and non‐Rh antibodies
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Monitoring of prenatal patients using a combined antibody titre for Rh and non‐Rh antibodies

机译：使用组合抗体滴度的产前患者进行RH和非RH抗体的监测

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Abstract Objectives This was a laboratory exercise designed to determine whether combined antibody titrations in the presence of multiple antibodies achieve a critical level earlier or at the same time as antibodies having individual antibody titrations. Background Management of haemolytic disease of the fetus and newborn involves monitoring maternal antibody concentration by antibody titration. Separate titrations are generally performed for each antibody. Method Thirty‐one samples containing combinations of two different Rh and/or non‐Rh antibodies were examined with separate titres for each antibody and one single combined titration. Results Of 31 samples, 19 (61.3%) showed an increased combined titre. Of 12 samples that showed no increase, 10 contained a separate titre of 1 for either one or both antibodies. Where both antibodies had a separate titre of ≥1, 15 of 17 (88.2%) showed an increased combined titre. In contrast to the separate titration method, no decrease in titre level was observed using the combined method. Conclusion Where two antibodies are present, titrations performed by a combined method will produce titre levels equal to or higher than antibodies titred individually. Therefore, a combined titration can be expected to reach a critical titre level as early as, or earlier in gestation than, antibodies monitored by a single titration method. Further studies relating fetal outcomes to titration methodology would be valuable in determining the validity of this approach for prenatal management. Cost‐effectiveness of this approach to prenatal screening should also be assessed.
机译：摘要目的这是一个实验室运动，旨在确定多种抗体存在的组合抗体滴定是否达到临界水平，或者与具有单个抗体滴定的抗体同时。胎儿和新生儿的溶血性疾病的背景管理涉及通过抗体滴定监测母体抗体浓度。通常对每种抗体进行单独的滴定。检查每种抗体的单独滴定和一个单一组合滴定的含有两种不同Rh和/或非-RH抗体的组合的三十一体样品。结果31种样品，19（61.3％）显示出增加的滴度。对于没有增加的12个样品，10含有一个或两种抗体的单独滴度。如果两种抗体都有单独的滴度≥1,15％（88.2％）显示出增加的滴度增加。与单独的滴定法相比，使用组合方法观察到滴度水平的降低。结论存在两种抗体，通过组合方法进行的滴定将产生等于或高于单独染色的抗体的滴度水平。因此，可以预期组合的滴定，早于妊娠的临界滴度水平而不是通过单个滴定法监测的抗体。进一步的研究与滴定方法相关的胎儿结果在确定这种方法对产前管理方法的有效性方面是有价值的。还应评估这种产前筛查方法的成本效益。

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