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Dynamics of early post-operative plasma ddcfDNA levels in kidney transplantation: a single-center pilot study

机译：肾移植早期术后血浆DDCFDNA水平的动态：单中心试验研究

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Donor-derived cell-free DNA (ddcfDNA) is reported to be a promising noninvasive biomarker for acute rejection in organ transplant. However, studies on monitoring ddcfDNA dynamics during the early periods after organ transplantation are scarce. Our study assessed the dynamic variation in ddcfDNA in early period with various types and status of kidney transplantation. Target region capture sequencing used identifies ddcfDNA level in 21 kidney transplant recipients. Median ddcfDNA level was 20.69% at the initial time post-transplant, and decreased to 5.22% on the first day and stayed at the stable level after the second day. The ddcfDNA level in DCD (deceased donors) group (44.99%) was significantly higher than that in LDRT (living donor) group (10.24%) at initial time, P DNA level in DGF (delayed graft function) recipients was lower (23.96%) than that in non-DGF (47.74%) at the initial time, P = 0.89 (19.34% in DGF and 4.46% in non-DGF on the first day, P = 0.17). DdcfDNA level at initial time significantly correlated with serum creatinine (r(2) = 0.219, P = 0.032) and warm ischemia time (r(2) = 0.204, P = 0.040). Plasma ddcfDNA level decreased rapidly follow an L-shaped curve post-transplant, and level in DGF declined slower than non-DGF. The rebound of ddcfDNA level may indicate the occurrence of acute rejection.
机译：据报道，供体衍生的无细胞DNA（DDCFDNA）是用于器官移植中的急性排斥反应的有希望的非侵入性生物标志物。然而，在器官移植后早期监测DDCFDNA动力学的研究是稀缺的。我们的研究评估了肾移植各种类型和地位的早期DDCFDNA的动态变化。目标区域捕获测序使用识别21例肾移植受体中的DDCFDNA水平。在移植后的初始时间，中位DDCFDNA水平为20.69％，在第一天减少至5.22％，并在第二天后保持稳定。 DCD（死者供体）组（44.99％）的DDCFDNA水平明显高于LDRT（活体供体）组（10.24％）在初始时间，DGF（延迟移植函数）受者的P DNA水平较低（23.96％） ）在初始时间的非DGF（47.74％）中，P = 0.89（DGF中的19.34％，在第一天的非DGF中为4.46％，P = 0.17）。在初始时间下的DDCFDNA水平与血清​​肌酐（R（2）= 0.219，P = 0.032）和温度缺血时间（R（2）= 0.204，P = 0.040）显着相关。血浆DDCFDNA水平迅速下降遵循后移植后L形曲线，DGF的水平越来越慢于非DGF。 DDCFDNA水平的反弹可能表明急性排斥的发生。

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