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首页> 外文期刊>Transplant international : >Thoracic muscle cross‐sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study
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Thoracic muscle cross‐sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

机译：胸部肌肉横截面区域与肺癌后肺癌的医院长度有关：回顾性队列研究

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Summary Low muscle mass is common in lung transplant ( LT x) candidates; however, the clinical implications have not been well described. The study aims were to compare skeletal muscle mass in LT x candidates with controls using thoracic muscle cross‐sectional area ( CSA ) from computed tomography and assess the association with pre‐ and post‐transplant clinical outcomes. This was a retrospective, single‐center cohort study of 527 LT x candidates [median age: 55 IQR (42–62) years; 54% male]. Thoracic muscle CSA was compared to an age‐ and sex‐matched control group. Associations between muscle CSA and pre‐transplant six‐minute walk distance (6 MWD ), health‐related quality of life ( HRQL ), delisting/mortality, and post‐transplant hospital outcomes and one‐year mortality were evaluated using multivariable regression analysis. Muscle CSA for LT x candidates was about 10% lower than controls ( n = 38). Muscle CSA was associated with pre‐transplant 6 MWD , but not HRQL , delisting or pre‐ or post‐transplant mortality. Muscle CSA (per 10 cm 2 difference) was associated with shorter hospital stay [0.7 median days 95% CI (0.2–1.3)], independent of 6 MWD . In conclusion, thoracic muscle CSA is a simple, readily available estimate of skeletal muscle mass predictive of hospital length of stay, but further study is needed to evaluate the relative contribution of muscle mass versus functional deficits in LT x candidates.
机译：发明内容低肌肉质量在肺移植（LT X）候选中是常见的;然而，临床意义尚未得到很好的描述。该研究旨在将骨骼肌质量与使用来自计算机断层扫描的胸部肌肉横截面积（CSA）进行比较，并评估与预移植后和后后临床结果的关联。这是一个回顾性的单中心队列的527 Lt X候选人[中位年龄：55 IQR（42-62）年; 54％的男性]。将胸肌CSA与年龄和性别匹配的对照组进行比较。使用多变量回归分析，评估肌肉CSA和移植前移植前六分钟步行距离（6 MWD），健康相关质量（HRQL），缺失/死亡率和移植后的一年死亡率。 LT X候选的肌肉CSA比对照减少约10％（n = 38）。肌肉CSA与移植前6 MWD相关，但不是HRQL，劳动或移植后或后期的死亡率。肌肉CSA（每10厘米2差异）与较短的住院住宿相关联[0.7中位数95％CI（0.2-1.3）]，独立于6 MWD。总之，胸肌CSA是一种简单，易于获得的骨骼肌肿大的估计，但需要进一步研究，以评估LT X候选者中肌肉质量与功能缺陷的相对贡献。

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