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首页> 外文期刊>Transplant international : >An analysis of the survival outcomes of simultaneous pancreas and kidney transplantation compared to live donor kidney transplantation in patients with type 1 diabetes: a UK UK Transplant Registry study
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An analysis of the survival outcomes of simultaneous pancreas and kidney transplantation compared to live donor kidney transplantation in patients with type 1 diabetes: a UK UK Transplant Registry study

机译：同时胰腺和肾移植的生存结果分析与1型糖尿病患者的活体肾移植相比：英国英国移植登记研究

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Summary Transplant options for patients with type 1 diabetes and end‐stage renal disease ( ESRD ) include deceased donor kidney, live donor kidney ( LDK ) and simultaneous pancreas‐kidney ( SPK ) transplantation. The aim of this study was to compare outcomes between LDK and SPK for patients with type 1 diabetes and ESRD in the UK . Data on all SPK ( n = 1739) and LDK ( n = 385) transplants performed between January 2001 and December 2014 were obtained from the UK Transplant Registry. Unadjusted patient and kidney graft survival were calculated using the Kaplan–Meier method. Multivariate analysis of kidney graft and patient survival was performed using Cox proportional hazards regression. There was no significant difference in patient ( P = 0.435) or kidney graft survival ( P = 0.204) on univariate analysis. On multivariate analysis there was no association between LDK / SPK and patient survival [ HR 0.71 (0.47–1.06), P = 0.095]. However, LDK was associated with an overall lower risk for kidney graft failure [ HR 0.60 (0.38–0.94), P = 0.025]. SPK recipients with a functioning pancreas graft had significantly better kidney graft and patient survival than LDK recipients or those with a failed pancreas graft. SPK transplantation does not confer an overall survival advantage compared to LDK . However, those SPK recipients with a functioning pancreas have significantly better outcomes.
机译：综述1型糖尿病患者和末期肾病（ESRD）的移植选项包括已故的供体肾，活体肾（LDK）和同时胰腺 - 肾（SPK）移植。本研究的目的是在英国1型糖尿病和ESRD的患者中比较LDK和SPK之间的结果。从英国移植登记处获得了2001年1月和2014年12月之间进行的所有SPK（n = 1739）和LDK（n = 385）移植的数据。使用Kaplan-Meier方法计算未经调整的患者和肾移植存活。使用Cox比例危害回归进行肾移植物和患者存活的多变量分析。在单变量分析上没有患者（P = 0.435）或肾移植存活率（P = 0.204）没有显着差异。在多变量分析上，LDK / SPK和患者存活之间没有关联[HR 0.71（0.47-1.06），P = 0.095]。然而，LDK与肾移植衰竭的总体风险较低有关[HR 0.60（0.38-0.94），P = 0.025]。具有功能性胰腺移植物的SPK接受者具有明显更好的肾移植物和患者存活，而不是LDK受体或胰腺移植失败的人。与LDK相比，SPK移植不会赋予整体存活优势。然而，那些具有功能胰腺​​的SPK受体具有更好的结果。

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