Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes

Gatchalian Jovylyn; Liao Jingwen; Maxwell Matthew B.; Hargreaves Diana C.

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Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes

机译：通过SWI / SNF染色质改造复合物控制巨噬细胞刺激依赖性反应

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Epigenetic regulation plays an important role in controlling the activation, timing, and resolution of innate immune responses in macrophages. Previously, SWI/SNF chromatin remodeling was found to define the kinetics and selectivity of gene activation in response to microbial ligands; however, these studies do not reflect a comprehensive understanding of SWI/SNF complex regulation. In 2018, a new variant of the SWI/SNF complex was identified with unknown function in inflammatory gene regulation. Here, we summarize the biochemical and genomic properties of SWI/SNF complex variants and the potential for increased regulatory control of innate immune transcriptional programs in light of such biochemical diversity. Finally, we review the development of SWI/SNF complex chemical inhibitors and degraders that could be used to modulate immune responses.

机译：表观遗传调节在控制巨噬细胞的激活，时序和分辨率方面发挥着重要作用。以前，发现SWI / SNF染色质重塑在响应微生物配体响应于微生物配体而定义基因活化的动力学和选择性; 然而，这些研究没有反映对SWI / SNF复杂监管的全面了解。 2018年，炎症基因调控中未知的功能鉴定了SWI / SNF复合物的新变体。在这里，我们总结了SWI / SNF复杂变体的生化和基因组特性，以及根据此类生化多样性鉴于先天免疫转录程序的调节控制的可能性。最后，我们回顾了可用于调节免疫应答的SWI / SNF复杂化学抑制剂和降解剂的开发。

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《Trends in immunology》 |2020年第2期|共15页
作者
Gatchalian Jovylyn; Liao Jingwen; Maxwell Matthew B.; Hargreaves Diana C.;
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作者单位

Salk Inst Biol Studies Mol &

Cell Biol Lab La Jolla CA 92037 USA;

Salk Inst Biol Studies Mol &

Cell Biol Lab La Jolla CA 92037 USA;

Salk Inst Biol Studies Mol &

Cell Biol Lab La Jolla CA 92037 USA;

Salk Inst Biol Studies Mol &

Cell Biol Lab La Jolla CA 92037 USA;

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正文语种 eng
中图分类医学免疫学;
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1. Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes [J] . Gatchalian Jovylyn, Liao Jingwen, Maxwell Matthew B., Trends in immunology . 2020,第2期

机译：通过SWI / SNF染色质改造复合物控制巨噬细胞刺激依赖性反应
2. Functional interplay between chromatin remodeling complexes RSC, SWI/SNF and ISWI in regulation of yeast heat shock genes [J] . A. M. Erkine, S. Freeling, T. Y. Erkina, Nucleic acids research . 2010,第5期

机译：染色质重塑复合物RSC，SWI / SNF和ISWI之间在调节酵母热激基因中的功能相互作用
3. Genetic analysis of functional redundancy of BRM ATPase and ATSWI3C subunits of Arabidopsis SWI/SNF chromatin remodelling complexes [J] . Rafal Archacki, Tomasz J. Sarnowski, Joanna Halibart-Puzio, Planta: An International Journal of Plant Biology . 2009,第6期

机译：拟南芥SWI / SNF染色质重塑复合物BRM ATPase和ATSWI3C亚单位功能冗余的遗传分析
4. Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands its Role in RNA Pol I Transcription. [C] . Yuan-Chin Tsai, Todd M. Greco, Apaporn Boonmee, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：功能性蛋白质组学建立了SIRT7与染色质重塑复合物的相互作用，并扩大其在RNA Pol I转录中的作用。
5. Organometallic photonucleases. I. DNA cleavage by the photolysis of cyclopentadienyl metal complexes: Mechanistic studies and sequence selectivity of strand scission by CpW(CO)3CH3. II. Footprinting of chromatin structure and chromatin remodeling by SWI/SNF utilizing CpW(CO)3CH3. III. Dual mechanisms of DNA damage by MoX(eta3-allyl)(CO)3(phen) complexes. [D] . Downs, Jennifer. 2005

机译：有机金属光核酸酶。 I.通过环戊二烯基金属配合物的光解来切割DNA：通过CpW（CO）3CH3进行断裂的机理研究和序列选择性。二。 SWI / SNF利用CpW（CO）3CH3进行染色质结构足迹测定和染色质重塑。三， MoX（eta3-烯丙基）（CO）3（phen）复合物对DNA的双重破坏机制。
6. MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF [O] . Evelyn Y. Chang, Helder Ferreira, Joanna Somers, -1

机译：MacroH2A可以通过SWI / SNF和ACF复合物实现ATP依赖的染色质重塑但可以专门减少SWI / SNF的招募
7. MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF [O] . Chang, Evelyn Y., Ferreira, Helder, Somers, Joanna, 2008

机译：MacroH2A可以通过SWI / SNF和ACF复合物实现ATP依赖的染色质重塑，但可以专门减少SWI / SNF的募集

Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes

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