Sleep Matters: CD4(+) T Cell Memory Formation and the Central Nervous System

Lange Tanja; Born Jan; Westermann Juergen

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Sleep Matters: CD4(+) T Cell Memory Formation and the Central Nervous System

机译：睡眠问题：CD4（+）T细胞记忆形成和中枢神经系统

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The mechanisms of CD4(+) T-cell memory formation in the immune system are debated. With the well-established concept of memory formation in the central nervous system (CNS), we propose that formation of CD4(+) T-cell memory depends on the interaction of two different cell systems handling two types of stored information. First, information about antigen (event) and challenge (context) is taken up by antigen-presenting cells, as initial storage. Second, event and context information is transferred to CD4(+) T cells. During activation, two categories of CD4(+) T cell develop: effector CD4(+) T cells, carrying event and context information, enabling them to efficiently focus their response to tissues under attack; and persisting CD4(+) T cells, providing context-independent antigen-specific memories and long-term storage. This novel hypothesis is supported by the observation that mammalian sleep can improve both CNS and CD4(+) T-cell memory.

机译：讨论了免疫系统中CD4（+）T细胞记忆形成的机制。通过中枢神经系统（CNS）中的内存形成良好的概念，我们提出了CD4（+）T细胞存储器的形成取决于处理两种类型存储信息的两个不同小区系统的相互作用。首先，通过抗原呈递细胞作为初始存储来占据有关抗原（事件）和挑战（上下文）的信息。其次，事件和上下文信息被传送到CD4（+）T细胞。在激活期间，两类CD4（+）T细胞发育：效应器CD4（+）T细胞，携带事件和上下文信息，使他们能够有效地将其对攻击中组织的响应关注; 并持久地持续CD4（+）T细胞，提供无关的抗原特定存储器和长期存储。这种新颖的假设得到了哺乳动物睡眠可以改善CNS和CD4（+）T细胞存储器的观察结果。

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《Trends in immunology》 |2019年第8期|共13页
作者
Lange Tanja; Born Jan; Westermann Juergen;
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作者单位

Univ Lubeck Clin Rheumatol &

Clin Immunol Ratzeburger Allee 160 D-23538 Lubeck Germany;

Univ Tubingen CIN Inst Med Psychol &

Behav Neurobiol Otfried Mueller Str 25 D-72076 Tubingen;

Univ Lubeck Inst Anat Ctr Struct &

Cell Biol Med Ratzeburger Allee 160 D-23538 Lubeck Germany;

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正文语种 eng
中图分类医学免疫学;
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1. Sleep Matters: CD4(+) T Cell Memory Formation and the Central Nervous System [J] . Lange Tanja, Born Jan, Westermann Juergen Trends in immunology . 2019,第8期

机译：睡眠问题：CD4（+）T细胞记忆形成和中枢神经系统
2. Induction of a central memory and stem cell memory phenotype in functionally active CD4(+) and CD8(+) CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19(+) acute lymphoblastic leukemia [J] . Blaeschke Franziska, Stenger Dana, Kaeuferle Theresa, Cancer immunology, immunotherapy : . 2018,第7期

机译：在用于治疗CD19（+）急性淋巴细胞白血病的自动化良好的制造实践系统中产生的功能活性CD4（+）和CD8（+）CAR T细胞中的中央记忆和干细胞记忆表型的诱导
3. Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system. [J] . J D Sedgwick, R M?ssner, S Schwender, The Journal of Experomental Medicine . 1991,第5期

机译：表达主要组织相容性复合体的非造血星形胶质细胞仅引发CD8 + T淋巴细胞：星形胶质细胞作为永存者，而不引发CD4 + T细胞在中枢神经系统中的反应。
4. Widespread expression of a-synuclein in neuronal cytoplasm and glial cells in the central and peripheral nervous systems in human [C] . Fumiaki Mori, Kunikazu Tanji, Makoto Yoshimoto, Hirosaki International Forum of Medical Science . 2003

机译：人类中枢神经和外周神经系统中神经元细胞质和神经胶质细胞的广泛表达
5. CD4(+) T cells and CD40-CD40L interactions mediate West Nile virus central nervous system clearance and protection from lethal infection. [D] . Farnsworth, Elizabeth Sitati. 2007

机译：CD4（+）T细胞和CD40-CD40L的相互作用介导了西尼罗河病毒中枢神经系统的清除和对致命感染的保护。
6. Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation [O] . Gordon B Feld, Ines Wilhem, Christian Benedict, 2016

机译：睡眠相关记忆形成和神经内分泌调节中的中枢神经胰岛素信号。
7. A Central Role for CD4+ T Cells and RANTES in Virus-Induced Central Nervous System Inflammation and Demyelination [O] . Lane, Thomas E., Liu, Michael T., Chen, Benjamin P., 2000

机译：CD4 + T细胞和RANTES在病毒诱导的中枢神经系统炎症和脱髓鞘中起核心作用

Sleep Matters: CD4(+) T Cell Memory Formation and the Central Nervous System

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