首页> 外文期刊>Trends in Microbiology >Plastic Circuits: Regulatory Flexibility in Fine Tuning Pathogen Success
【24h】

Plastic Circuits: Regulatory Flexibility in Fine Tuning Pathogen Success

机译:塑料电路:微调病原体成功的调节灵活性

获取原文
获取原文并翻译 | 示例
           

摘要

Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle -specific traits require integration into the regulatory network of the cell and are often controlled by pre-existing transcription factors. In this review, we highlight recent advances that have been made in characterizing this regulatory flexibility in prominent members of the Enterobacteriaceae. We focus on the direct global interactions between transcription factors and their target genes in pathogenic Escherichia coil and Salmonella revealed using chromatin immunoprecipitation coupled with next generation sequencing. Furthermore, the implications and advantages of such regulatory adaptations in benefiting distinct pathogenic lifestyles are discussed.
机译:细菌病原体采用不同的健康和毒力机制,以获得竞争性的利基中的优势。 这些生活方式的特定性状需要集成到细胞的调节网络中,并且通常由预先存在的转录因子控制。 在这篇综述中,我们突出了最近的进展,这是在肠杆菌的突出成员中表征这种调节灵活性。 我们专注于转录因子与其靶基因之间的直接全球相互作用,在致病大肠杆菌和奶酪中透露使用染色质免疫沉淀和下一代测序偶联的沙门氏菌。 此外,讨论了在有益于不同的致病生活方式中这种调节调节的影响和优点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号