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Evolutionary Constraints Shaping Streptococcus pyogenes-Host Interactions

机译：进化约束塑造链球菌性肽 - 宿主交互

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摘要

Research on the Gram-positive human-restricted pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) has long focused on invasive illness, the most severe manifestations of GAS infection. Recent advances in descriptions of molecular mechanisms of GAS virulence, coupled with massive sequencing efforts to isolate genomes, have allowed the field to better understand the molecular and evolutionary changes leading to pandemic strains. These findings suggest that it is necessary to rethink the dogma involving GAS pathogenesis, and that the most productive avenues for research going forward may be investigations into GAS in its 'normal' habitat, the nasopharynx, and its ability to either live with its host in an asymptomatic lifestyle or as an agent of superficial infections. This review will consider these advances, focusing on the natural history of GAS, the evolution of pandemic strains, and novel roles for several key virulence factors that may allow the field to better understand their physiological role.
机译：研究革兰氏阳性人类受限制的病原体链球菌（群群中，链球菌，气体）长期以来一直关注侵袭性疾病，是气体感染最严重的表现。关于气体毒力分子机制的最新进展，与孤立基因组的大规模测序努力相结合，使该领域能够更好地了解导致大流行菌株的分子和进化变化。这些研究结果表明，有必要重新思考涉及煤气发病机制的教条，并且最富有成效的研究途径可能会在其“正常”栖息地，鼻咽，鼻咽和其主持人中的能力调查天然气无症状的生活方式或浅表感染的代理。本综述将考虑这些进展，重点是天然气的自然历史，大流行菌株的演变，以及几个关键毒力因子的新角色可能让现场更好地了解其生理作用。

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