<ce:italic>Mycobacterium tuberculosis:</ce:italic> prePPARing and Maintaining the Replicative Niche

Michael D. Stutz; Marc Pellegrini

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Mycobacterium tuberculosis: prePPARing and Maintaining the Replicative Niche

机译：结核分枝杆菌：预制备和维护复制的利基

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Mycobacterium tuberculosisinterferes with the ability of its host cell to undergo apoptosis. Arnettet al.report that the pathogen promotes macrophage survival by engaging the nuclear receptor PPARγ to induce the antiapoptotic protein MCL-1, yielding insights into the pathogenesis of tuberculosis and potentially unlocking new avenues for therapeutic intervention.

机译：结核分枝杆菌有能力，其宿主细胞进行细胞凋亡。 Arnettet Al.Report通过将核受体PPARγ接合诱导抗透露蛋白MCL-1来促进巨噬细胞存活，从而屈服于结核病发病机制，并潜在解锁新途径进行治疗干预。

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来源
《Trends in Microbiology》 |2018年第10期|共2页
作者
Michael D. Stutz; Marc Pellegrini;
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作者单位

Infection and Immunity Division The Walter and Eliza Hall Institute of Medical Research;

Infection and Immunity Division The Walter and Eliza Hall Institute of Medical Research;

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原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词
tuberculosis; apoptosis; PPARγ; MCL-1; host-directed therapy;

机译：结核病;细胞凋亡;PPARγ;MCL-1;宿主定向治疗;

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1. Mycobacterium tuberculosis: prePPARing and Maintaining the Replicative Niche [J] . Michael D. Stutz, Marc Pellegrini Trends in Microbiology . 2018,第10期

机译：结核分枝杆菌：预制备和维护复制的利基
2. Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection [J] . Lingjun Zhan, Jun Tang, Shuzhu Lin, Frontiers in Microbiology . 2015,第6期

机译：灵芝提取物的预防性使用可抑制结核分枝杆菌在自发性潜伏性结核感染新小鼠模型中的复制
3. Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection [J] . Lingjun Zhan, Jun Tang, Shuzhu Lin, Frontiers in Microbiology . 2015,第6期

机译：灵芝提取物的预防性使用可抑制结核分枝杆菌在自发性潜伏性结核感染新小鼠模型中的复制
4. The Development of Hanwen Regular Script and Its Influence on Italic Typography [C] . Zhengying Wang International Conference on Art Studies: Science, Experience, Education . 2019

机译：汉文常规剧本的发展及其对斜体排版的影响
5. Targeting non-replicating populations of Mycobacterium tuberculosis: Focusing on disrupting intrabacterial pH homeostasis. [D] . Darby, Crystal Mae. 2011

机译：针对结核分枝杆菌的非复制人群：专注于破坏细菌内pH稳态。
6. Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis [O] . Thomas R. Lerner, Cristiane de Souza Carvalho-Wodarz, Urska Repnik, 2016

机译：淋巴管内皮细胞是结核分枝杆菌的复制位
7. Novel connections between DNA replication, telomere homeostasis and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae [O] . Piening, Brian Donald 2013

机译：全基因组筛选酿酒酵母中的 TEL1 / ATM 相互作用的DNA复制，端粒稳态和DNA损伤反应之间的新型联系

Mycobacterium tuberculosis: prePPARing and Maintaining the Replicative Niche

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