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Did Zika Virus Mutate to Cause Severe Outbreaks?

机译:Zika病毒是否突变导致严重爆发?

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Zika virus (ZIKV) has challenged the assumed knowledge regarding the pathobiology of flaviviruses. Despite causing sporadic and mild disease in the 50 years since its discovery, Zika virus has now caused multiple outbreaks in dozens of countries worldwide. Moreover, the disease severity in recent outbreaks, with neurological disease in adult and devastating congenital malformations in fetuses, was not previously seen. One hypothesis is that the virus has acquired mutations that have increased its virulence. Indeed, mutations in other arboviruses, such as West Nile virus (WNV), chikungunya virus (CHIKV), and Venezuelan equine encephalitis virus (VEEV), have enhanced outbreaks. This possibility, as well as alternative hypotheses, are explored here.
机译:Zika病毒(ZIKV)挑战了关于黄病毒病病病病病病毒学的知识。 尽管自发现以来的50年来引起孢子和轻度疾病,但Zika病毒现已在全球数十个国家造成多种爆发。 此外,在最近爆发的疾病严重程度,以前没有看到成人中的神经疾病和胎儿的先天性畸形。 一个假设是病毒已经获得了增加毒力的突变。 实际上,其他遗治的突变,例如西尼罗病毒(WNV),Chikungunya病毒(Chikv)和委内瑞拉大核脑炎病毒(VEEV),具有增强的爆发。 这里探索这种可能性以及替代假设。

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