Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Voet Sofie; Prinz Marco; van Loo Geert

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Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

机译：中枢神经系统炎症和多发性硬化病理学的微胶质

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Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuroinflammatory and neuroprotective properties, illustrating the plasticity of these cells. Recent progress in understanding the autoimmune neuroinflammatory disease multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis suggests major roles for microglia in the disease, which have drastically changed our view on the function of microglia in MS.

机译：微胶质细胞是中枢神经系统（CNS）的常规巨噬细胞。它们在维持组织稳态中具有重要的生理功能，但也有助于CNS病理学。微胶质细胞对微环境的变化作出反应，并且所得的反应性表型可以非常多样化，具有神经炎性和神经保护性，说明这些细胞的可塑性。理解自身免疫性神经炎性疾病多发性硬化症（MS）及其动物模型实验性自身免疫脑髓炎的最新进展表明对疾病中的小胶质细胞的主要作用，这彻底改变了我对MS中微胶质植物的功能的看法。

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来源
《Trends in molecular medicine》 |2019年第2期|共12页
作者
Voet Sofie; Prinz Marco; van Loo Geert;
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作者单位

VIB Ctr Inflammat Res Ghent Belgium;

Univ Freiburg Inst Neuropathol Fac Med Freiburg Germany;

VIB Ctr Inflammat Res Ghent Belgium;

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原文格式 PDF
正文语种 eng
中图分类分子生物学;
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1. Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology [J] . Voet Sofie, Prinz Marco, van Loo Geert Trends in molecular medicine . 2019,第2期

机译：中枢神经系统炎症和多发性硬化病理学的微胶质
2. TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies [J] . Philippa Malko, Sharifah A. Syed Mortadza, Joseph McWilliam, Frontiers in Pharmacology . 2019,第8期

机译：小胶质细胞中的TRPM2通道是神经炎症与中枢神经系统病理频谱相关的新参与者
3. Significance of elevated Prohibitin 1 levels in Multiple Sclerosis patients lymphocytes towards the assessment of subclinical disease activity and its role in the central nervous system pathology of disease [J] . Kumar Madathiparambil Kumaran Satheesh, Nair Sreepriya, Mony Ullas, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2018,第期

机译：多发性硬化症患者淋巴细胞中升高的PROHBITIN 1水平的意义对亚临床疾病活动评估及其在疾病中枢神经系统病理中的作用
4. Optimalization Of NMR Micro Imaging (1.9T, 4.7T, 7.4T) Of The Central Nervous System Of An Animal Model For Multiple Sclerosis [C] . Donimisse R., Lanens D., Spanoghe M., Engineering in Medicine and Biology Society, 1991. Vol.13: 1991., Proceedings of the Annual International Conference of the IEEE . 1991

机译：多发性硬化症动物模型中枢神经系统NMR微成像（1.9T，4.7T，7.4T）的优化
5. The role of inflammation in secondary pathology following central nervous system injury. [D] . Fitch, Michael Thomas. 1999

机译：中枢神经系统损伤后炎症在继发性病理中的作用。
6. Microglia as Liaisons Between the Immune and Central Nervous Systems: Functional Implications for Multiple Sclerosis [O] . Monica J. Carson -1

机译：小胶质细胞作为免疫系统和中枢神经系统之间的联络人：多发性硬化症的功能含义。
7. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis [O] . Monica J. Carson 2014

机译：小胶质细胞作为免疫和中枢神经系统之间的联络人：对多发性硬化症的功能影响
8. In Vivo Imaging of Cortical Inflammation and Subpial Pathology in Multiple Sclerosis by Combined PET and MRI. [R] . Mainero, C. 2016

机译：通过组合pET和mRI在多发性硬化症的皮层炎症和皮下病理的体内成像。

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

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