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首页> 外文期刊>Tropical Animal Health and Production >Evaluation of genetic and non-genetic factors on foot and mouth disease (FMD) virus vaccine-elicited immune response in Hardhenu (Bos taurus x Bos indicus) cattle
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Evaluation of genetic and non-genetic factors on foot and mouth disease (FMD) virus vaccine-elicited immune response in Hardhenu (Bos taurus x Bos indicus) cattle

机译：遗传和非遗传因素对脚下病毒（FMD）病毒疫苗引发免疫反应的遗传和非遗传因素评估（Bos Taurus X Bos indus ind）牛

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Foot and mouth disease (FMD) is the most contagious disease of mammals and a major threat to animal husbandry sector. In India, vaccination with the inactivated trivalent (O, A and Asia1) vaccine is one proven way for protecting the livestock from FMD. However, many outbreaks have been reported in different parts of the country. Therefore, present study was aimed at elucidating the effects of genetic and non-genetic factors on FMD viral vaccine-elicited immune response in Hardhenu cattle. The effect of season of vaccination was not consistent. The effect of status of animal was significant for all the pre and post AB titres except for pre AB titre of serotype O and post AB titre of Asia1.The estimates of heritability for response to vaccination were low to high ranging from 0.11 to 0.45. The highest heritability estimate was obtained for serotype O and the lowest for Asia1. The heritability estimates for pre and post AB titres ranged from 0.15 to 0.33. All the pre and post AB titres and responses to vaccination had genetic correlations ranged from high negative to high positive among them. Results of this study highlight the variation in vaccine response which needs to be further exploited on large-scale animal data for better immunization and protection against highly contagious viral vesicular disease of cloven-hoofed animals.
机译：脚口病（FMD）是哺乳动物最具传染病的疾病和对畜牧业部门的主要威胁。在印度，与灭活三价（o，a和asia1）疫苗接种疫苗是保护牲畜免受fmd的一种成熟方式。但是，在该国不同地区报告了许多爆发。因此，目前的研究旨在阐明遗传和非遗传因素对硬熟牛的FMD病毒疫苗引发免疫应答的影响。疫苗接种季节的效果并不一致。除了血清型o和亚洲的初级滴度之外，动物的状态的效果是显着的。除了血吸虫滴度和亚洲的滴度之外的滴度。对疫苗接种的反应的遗传性估计低于0.11至0.45的高度。血清型o和亚洲最低的最高遗传性估计。预先和后AB滴度的遗传性估计范围为0.15至0.33。所有前AB滴度和对疫苗接种的反应都具有遗传相关性，从而从高负至高阳性。本研究的结果突出了疫苗响应的变化，需要进一步利用大规模动物数据，以便更好地免疫和防止偶蹄动物的高传染性病毒尿布疾病。

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