Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function

Sytnyk Vladimir; Leshchynska Iryna; Schachner Melitta

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Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function

机译：免疫球蛋白超家族调节突触形成，维护和功能的神经细胞粘附分子

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Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in vertebrate and invertebrate nervous systems. Prominent family members are the neural cell adhesion molecules NCAM and L1, which were the first to be shown to be essential not only in development but also in synaptic function and as key regulators of synapse formation, synaptic activity, plasticity, and synaptic vesicle recycling at distinct developmental and activity stages. In addition to interacting with each other, adhesion molecules interact with ion channels and cytokine and neurotransmitter receptors. Mutations in their genes are linked to neurological disorders associated with abnormal development and synaptic functioning. This review presents an overview of recent studies on these molecules and their crucial impact on neurological disorders.

机译：免疫球蛋白超家族粘附分子是脊椎动物和无脊椎动物神经系统中最丰富的蛋白质中。突出的家庭成员是NCAM和L1的神经细胞粘附分子NCAM和L1，这是第一个不仅在发育中所必需的必需品，而且是突触函数，也是突触形成，突触活动，可塑性和突触囊泡回收的关键调节因子明显的发展和活动阶段。除了彼此相互作用之外，粘附分子与离子通道和细胞因子和神经递质受体相互作用。它们基因中的突变与与异常发育和突触功能相关的神经系统紊乱。本综述概述了最近对这些分子的研究及其对神经疾病的关键影响。

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来源
《Trends in Neurosciences》 |2017年第5期|共14页
作者
Sytnyk Vladimir; Leshchynska Iryna; Schachner Melitta;
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作者单位

Univ New South Wales Sch Biotechnol &

Biomol Sci Sydney NSW 2052 Australia;

Univ New South Wales Sch Biotechnol &

Biomol Sci Sydney NSW 2052 Australia;

Shantou Univ Med Coll Ctr Neurosci Shantou 515041 Guangdong Peoples R China;

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正文语种 eng
中图分类神经病学;
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专利

1. Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function [J] . Sytnyk Vladimir, Leshchynska Iryna, Schachner Melitta Trends in Neurosciences . 2017,第5期

机译：免疫球蛋白超家族调节突触形成，维护和功能的神经细胞粘附分子
2. Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation [J] . Rui P. A. Tan, Iryna Leshchyns’ka, Vladimir Sytnyk Frontiers in Molecular Neuroscience . 2017,第10期

机译：糖基磷脂酰肌醇固定的免疫球蛋白超家族细胞粘附分子及其在神经元发育和突触调节中的作用
3. Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair [J] . Yi Zhang John Yeh Peter M. Richardson and Xuenong Bo Restorative Neurology and Neuroscience . 2008,第2a3期

机译：免疫球蛋白超家族的细胞黏附分子在轴突再生和神经修复中的作用
4. Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient [C] . Masaya Hane, Mizuki Sumida, Ken Kitajima IUPAC World Congress on Chemistry . 2015

机译：通过精神分裂症患者的突变多糖苷结合酶合成的聚脲酸（POWYSIA）粘附分子（NCAM）的结构和功能损伤
5. Single cell analysis of multiple intracellular processes: ICAM-2/LFA-1 interactions as functional adhesion molecules of the immunological synapse. [D] . Perez, Omar David. 2003

机译：多个细胞内过程的单细胞分析：ICAM-2 / LFA-1相互作用作为免疫突触的功能性粘附分子。
6. Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation [O] . Rui P. A. Tan, Iryna Leshchyns’ka, Vladimir Sytnyk 2017

机译：糖基磷脂酰肌醇固定的免疫球蛋白超家族细胞粘附分子及其在神经元发育和突触调节中的作用
7. Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian [O] . Eri Fusaoka, Takeshi Inoue, Katsuhiko Mineta, 2006

机译：原始免疫球蛋白超家族神经细胞粘附分子的结构和功能：普林斯研究中研究的课程
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function

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